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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-7-29
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pubmed:abstractText |
KISS1 was first discovered as a metastasis suppressor, but also plays crucial roles in the onset of puberty. The KISS1 gene encodes a secreted protein of 145 amino acids that exhibits no sequence similarity with any known proteins. KISS1 protein is proteolytically processed to generate a number of so-called kisspeptins (KP), the most well characterized is known as KP-54 or metastin. KP-54 is carboxy-terminally amidated and binds to and activates the KISS1 receptor (KISS1R). The current studies were undertaken in order to determine structure of KP-54 using nuclear magnetic resonance and circular dichroism. KP-54 is mostly disordered both in water and in trifluoroethanol/water mixed solvent, with no structural motifs. In sodium dodecyl sulfate micelles, KP-54 remains mostly disordered except for a small increase in helical propensity (from 3.7% in water to 9.9% in micelles). Despite this apparent lack of structure, KP-54 is biologically active. The intrinsic disorder of KP-54 may confer advantages in its ability to recognize and bind a wide range of target proteins.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-10070750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-10845559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-11170201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-11385580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-11387329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-11457843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-12543799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-15087392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-15609993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-15980571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-16283480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-17145717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-17266198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-17312308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-17473845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-17512859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-18280770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-18515314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-18765263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-18775461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-18989306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-19308680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-8520220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-8944003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-9185708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-9192814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19308666-9806840
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1573-7276
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
527-33
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
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pubmed:year |
2009
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pubmed:articleTitle |
Nuclear magnetic resonance and circular dichroism study of metastin (Kisspeptin-54) structure in solution.
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pubmed:affiliation |
Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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