Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-9-23
pubmed:abstractText
Impairment of glucose metabolism (in particular insulin resistance and type 2 diabetes mellitus) has been reported in patients who have undergone hematopoietic SCT (HSCT) during childhood, especially those treated with TBI. This pilot study was conducted to determine prevalence of and possible underlying mechanisms for impaired glucose homeostasis in young adults treated with HSCT and TBI and who were not previously known to have diabetes mellitus. A total of 10 subjects (6 males, 4 females) were evaluated. Mean ages were 13.0+/-1.0 years at the time of TBI and 24.0+/-1.1 years at the time of this study. Five subjects had laboratory evidence of insulin resistance using the homeostasis model assessment and the quantitative insulin sensitivity check index indices. Two of these subjects had impaired fasting glucose and four had decreased plasma insulin-like growth factor 1 levels. All 10 subjects had evidence of abdominal obesity. Insulin resistance is frequently observed in adult survivors of HSCT treated with TBI in childhood. Underlying mechanisms may include radiation-induced growth hormone deficiency and changes in body composition.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1476-5365
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
339-43
pubmed:meshHeading
pubmed-meshheading:19308039-Adolescent, pubmed-meshheading:19308039-Adult, pubmed-meshheading:19308039-Blood Glucose, pubmed-meshheading:19308039-Body Mass Index, pubmed-meshheading:19308039-Cranial Irradiation, pubmed-meshheading:19308039-Disease-Free Survival, pubmed-meshheading:19308039-Female, pubmed-meshheading:19308039-Follow-Up Studies, pubmed-meshheading:19308039-Glucose Intolerance, pubmed-meshheading:19308039-Hematopoietic Stem Cell Transplantation, pubmed-meshheading:19308039-Homeostasis, pubmed-meshheading:19308039-Humans, pubmed-meshheading:19308039-Insulin Resistance, pubmed-meshheading:19308039-Insulin-Like Growth Factor I, pubmed-meshheading:19308039-Male, pubmed-meshheading:19308039-Obesity, Abdominal, pubmed-meshheading:19308039-Pilot Projects, pubmed-meshheading:19308039-Prevalence, pubmed-meshheading:19308039-Survivors, pubmed-meshheading:19308039-Transplantation Conditioning, pubmed-meshheading:19308039-Whole-Body Irradiation, pubmed-meshheading:19308039-Young Adult
pubmed:year
2009
pubmed:articleTitle
Disorders of glucose homeostasis in young adults treated with total body irradiation during childhood: a pilot study.
pubmed:affiliation
Department of Pediatric Endocrinology, New York Presbyterian Hospital-Weill Cornell Medical College and Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't