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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
2009-4-8
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pubmed:abstractText |
Wnt signaling through beta-catenin and TCF maintains preadipocytes in an un-differentiated proliferative state; however, the molecular pathway has not been completely defined. By integrating gene expression microarray, chromatin immunoprecipitation-chip, and cell-based experimental approaches, we show that Wnt/beta-catenin signaling activates the expression of COUP-TFII which recruits the SMRT corepressor complex to the first introns located downstream from the first exons of both PPARgamma1 and gamma2 mRNAs. This maintains the local chromatin in a hypoacetylated state and represses PPARgamma gene expression to inhibit adipogenesis. Our experiments define the COUP-TFII/SMRT complex as a previously unappreciated component of the linear pathway that directly links Wnt/beta-catenin signaling to repression of PPARgamma gene expression and the inhibition of adipogenesis.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19307559-10201372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19307559-10409758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19307559-10898789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19307559-10937998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19307559-11782441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19307559-12509515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19307559-12791265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19307559-14529150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19307559-14661024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19307559-15060163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19307559-15175259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19307559-16415884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19307559-16793414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19307559-16895995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19307559-17085012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19307559-17114293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19307559-17139329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19307559-17488638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19307559-18250317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19307559-9065401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19307559-9171235
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/COUP Transcription Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Chromatin,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ncor2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ncor2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Co-Repressor 2,
http://linkedlifedata.com/resource/pubmed/chemical/PPAR gamma,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1091-6490
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pubmed:author |
pubmed-author:AburataniHiroyukiH,
pubmed-author:HamakuboTakaoT,
pubmed-author:ItoSadayoshiS,
pubmed-author:KodamaTatsuhikoT,
pubmed-author:KudoHiromiH,
pubmed-author:NaitoMakotoM,
pubmed-author:NonakaAyaA,
pubmed-author:OkamuraMasashiM,
pubmed-author:OsborneTimothy FTF,
pubmed-author:SakaiJuroJ,
pubmed-author:SakakibaraIoriI,
pubmed-author:TanakaToshiyaT,
pubmed-author:TsutsumiShuichiS,
pubmed-author:UchidaAoiA,
pubmed-author:WakabayashiKen-ichiK,
pubmed-author:YanagisawaMasashiM
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pubmed:issnType |
Electronic
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pubmed:day |
7
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5819-24
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19307559-Acetylation,
pubmed-meshheading:19307559-Adipogenesis,
pubmed-meshheading:19307559-Animals,
pubmed-meshheading:19307559-COUP Transcription Factor I,
pubmed-meshheading:19307559-Chromatin,
pubmed-meshheading:19307559-DNA-Binding Proteins,
pubmed-meshheading:19307559-Gene Expression Regulation,
pubmed-meshheading:19307559-Mice,
pubmed-meshheading:19307559-Nuclear Receptor Co-Repressor 2,
pubmed-meshheading:19307559-PPAR gamma,
pubmed-meshheading:19307559-RNA, Messenger,
pubmed-meshheading:19307559-Rats,
pubmed-meshheading:19307559-Repressor Proteins,
pubmed-meshheading:19307559-Signal Transduction,
pubmed-meshheading:19307559-Wnt Proteins,
pubmed-meshheading:19307559-beta Catenin
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pubmed:year |
2009
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pubmed:articleTitle |
COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis.
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pubmed:affiliation |
Laboratory of Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, 4-6-1, Komaba, Meguro-ku, Tokyo 153-8904, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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