Linked Life Data

1930722

Source:http://linkedlifedata.com/resource/pubmed/id/1930722

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-12-26
pubmed:abstractText
Hungary rats were exposed to a conditioned stimulus (CS) event (either light onset or offset) before food delivery. After several weeks of contingent CS+/food pairings, animals were pretreated with either 0, 0.5, 0.75, or 1.0 mg/kg pimozide and exposed to the CS+ alone. Both vehicle- and neuroleptic-treated rats showed large elevations in locomotor activity immediately after CS+ presentation, in relation to pre-CS+ activity levels. This elevation in activity was apparently due to the conditioned motivational properties of the stimulus because animals that had previously received unpaired presentations of the CS and food failed to show similar responsiveness to the CS. Although pimozide did not affect responsiveness to the CS+, the neuroleptic did produce an overall suppression of locomotor activity during both pre- and post-CS+ periods. The results suggest that neuroleptic treatment produces a suppression of general activity but leaves the motivational properties of food-paired stimuli intact.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0735-7044
pubmed:author
pubmed:issnType
Print
pubmed:volume
105
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
536-41
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Conditioned incentive properties of a food-paired conditioned stimulus remain intact during dopamine receptor blockade.
pubmed:affiliation
Behavioral Pharmacology Laboratory, University of California, Santa Barbara 93106.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.