|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0013878,
umls-concept:C0021368,
umls-concept:C0024485,
umls-concept:C0026769,
umls-concept:C0030705,
umls-concept:C0060240,
umls-concept:C0205219,
umls-concept:C0386370,
umls-concept:C0456644,
umls-concept:C0682708,
umls-concept:C1524063,
umls-concept:C2349975,
umls-concept:C2603343
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|
pubmed:issue |
4
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|
pubmed:dateCreated |
2009-3-26
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|
pubmed:abstractText |
To explore ultrasmall superparamagnetic particles of iron oxide (USPIO) as a marker for diffuse inflammation in multiple sclerosis (MS) normal-appearing white matter (NAWM), using quantitative MRI. Disease activity in the NAWM of MS patients partly explains why MRI lesion burden correlates only moderately with disability. USPIO have been shown to visualize the cellular component of inflammation in focal MS lesions. In this study, we aimed to explore USPIO as a marker for the more diffuse inflammation in MS NAWM, using quantitative MRI.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
1053-1807
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
29
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
774-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19306366-Adult,
pubmed-meshheading:19306366-Case-Control Studies,
pubmed-meshheading:19306366-Contrast Media,
pubmed-meshheading:19306366-Dextrans,
pubmed-meshheading:19306366-Female,
pubmed-meshheading:19306366-Ferumoxytol,
pubmed-meshheading:19306366-Humans,
pubmed-meshheading:19306366-Iron,
pubmed-meshheading:19306366-Magnetic Resonance Imaging,
pubmed-meshheading:19306366-Magnetite Nanoparticles,
pubmed-meshheading:19306366-Male,
pubmed-meshheading:19306366-Middle Aged,
pubmed-meshheading:19306366-Multiple Sclerosis,
pubmed-meshheading:19306366-Oxides,
pubmed-meshheading:19306366-Particle Size,
pubmed-meshheading:19306366-Prospective Studies,
pubmed-meshheading:19306366-Statistics, Nonparametric
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|
pubmed:year |
2009
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|
pubmed:articleTitle |
Use of ultrasmall superparamagnetic particles of iron oxide (USPIO)-enhanced MRI to demonstrate diffuse inflammation in the normal-appearing white matter (NAWM) of multiple sclerosis (MS) patients: an exploratory study.
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|
pubmed:affiliation |
Department of Neurology, MS Centre Amsterdam, Amsterdam, the Netherlands. m.vellinga@vumc.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
