Source:http://linkedlifedata.com/resource/pubmed/id/19306339
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2009-7-9
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pubmed:abstractText |
The aim of the study was to assess the influence of carbogen (95% O(2), 5% CO(2)) or pure oxygen breathing on renal oxygenation measured by blood oxygenation level dependent (BOLD) magnetic resonance imaging at 3.0 T. Seven healthy young volunteers (median age 25, range 23-35 years) participated in the study. A T2*-weighted fat-saturated spoiled gradient-echo sequence was implemented on a 3.0 T whole-body imager (TE/TR = 27.9 ms/49 ms, excitation angle 20 degrees ) with an acquisition time of approximately 5.3 s. A total of 100 images were acquired during 22 min. A block design was applied for gas administration: 4 min room air, 4 min carbogen/oxygen, 4 min room air, 4 min carbogen/oxygen and 6 min room air. A compartment model was fitted to the data sets accounting for time-dependent increase/decrease of renal oxygenation as well as baseline changes of the scanner. T2*-weighted images showed good image quality without notable artefacts or distortions. Mean relative signal increase due to carbogen breathing was 2.73% (95% confidence interval: 1.34-5.54) in the right kidney and 3.76% (1.53-9.20) in the left kidney, while oxygen breathing led to a signal enhancement of 3.20% (2.57-3.98) in the right kidney and 3.16% (1.83-5.45) in the left kidney. No statistical difference was found between carbogen and oxygen breathing or between the oxygenation of the right and the left kidney. A significant difference was found in the characteristic time constant for the signal increase with a faster saturation taking place for oxygen breathing. Renal tissue oxygenation is clearly influenced by carbogen or oxygen breathing. The changes can be assessed by T2*-weighted MRI at high field strengths. The effects are in the expected range for the BOLD effect of 3-4% at 3.0 T. The proposed technique might be interesting for the assessment of renal tissue oxygenation and its regulation in patients with kidney diseases.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1099-1492
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pubmed:author | |
pubmed:copyrightInfo |
Copyright (c) 2009 John Wiley & Sons, Ltd.
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pubmed:issnType |
Electronic
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
638-45
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pubmed:meshHeading |
pubmed-meshheading:19306339-Adult,
pubmed-meshheading:19306339-Carbon Dioxide,
pubmed-meshheading:19306339-Female,
pubmed-meshheading:19306339-Humans,
pubmed-meshheading:19306339-Kidney,
pubmed-meshheading:19306339-Magnetic Resonance Imaging,
pubmed-meshheading:19306339-Male,
pubmed-meshheading:19306339-Oxygen,
pubmed-meshheading:19306339-Oxygen Consumption,
pubmed-meshheading:19306339-Respiration,
pubmed-meshheading:19306339-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Influence of oxygen and carbogen breathing on renal oxygenation measured by T2*-weighted imaging at 3.0 T.
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pubmed:affiliation |
Section of Experimental Radiology, Eberhard-Karls University, Hoppe-Seyler-Strasse 3, Tübingen, Germany. andreas.boss@med.uni-tuebingen.de
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pubmed:publicationType |
Journal Article
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