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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0024432,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0205225,
umls-concept:C0699040,
umls-concept:C0851285,
umls-concept:C1412058,
umls-concept:C1417108,
umls-concept:C2246761,
umls-concept:C2911684
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pubmed:issue |
6
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pubmed:dateCreated |
2009-5-21
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pubmed:abstractText |
ATP-binding cassette transporter A1 (ABCA1) is thought to lipidate apolipoprotein A-I (apoA-I) at the plasma membrane, with endosomal cholesterol contributing as substrate. The mechanisms of ABCA1 surface delivery are not well understood. We have shown that Rab8 regulates endosomal cholesterol removal to apoA-I in human fibroblasts. Here, we investigated whether Rab8 plays a role in ABCA1 plasma membrane expression and cholesterol removal in primary human macrophages.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/APOA1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ATP binding cassette transporter 1,
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein A-I,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/RAB8A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/rab GTP-Binding Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
883-8
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pubmed:meshHeading |
pubmed-meshheading:19304576-ATP-Binding Cassette Transporters,
pubmed-meshheading:19304576-Apolipoprotein A-I,
pubmed-meshheading:19304576-Biological Transport,
pubmed-meshheading:19304576-Cell Membrane,
pubmed-meshheading:19304576-Cells, Cultured,
pubmed-meshheading:19304576-Cholesterol,
pubmed-meshheading:19304576-Coronary Artery Disease,
pubmed-meshheading:19304576-Endosomes,
pubmed-meshheading:19304576-Foam Cells,
pubmed-meshheading:19304576-Humans,
pubmed-meshheading:19304576-Protein Transport,
pubmed-meshheading:19304576-RNA, Small Interfering,
pubmed-meshheading:19304576-RNA Interference,
pubmed-meshheading:19304576-Transfection,
pubmed-meshheading:19304576-rab GTP-Binding Proteins
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pubmed:year |
2009
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pubmed:articleTitle |
Rab8 regulates ABCA1 cell surface expression and facilitates cholesterol efflux in primary human macrophages.
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pubmed:affiliation |
Institute of Biomedicine/Anatomy, Haartmaninkatu 8, 00014 University of Helsinki, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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