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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-5-11
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pubmed:abstractText |
Preoperative chemotherapy and radiation has become the standard of care for many patients with rectal cancer. The therapy may have toxicity and delays definitive surgery. It would therefore be desirable to identify those cancers that will not regress with preoperative therapy. We assessed a series of rectal cancers for the molecular changes of loss of heterozygosity of the APC and DCC genes, K-ras mutations, and microsatellite instability, changes that have clearly been associated with rectal carcinogenesis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1879-355X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
472-6
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pubmed:dateRevised |
2009-9-14
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pubmed:meshHeading |
pubmed-meshheading:19304403-Aged,
pubmed-meshheading:19304403-Biopsy,
pubmed-meshheading:19304403-Colorectal Neoplasms,
pubmed-meshheading:19304403-Combined Modality Therapy,
pubmed-meshheading:19304403-Female,
pubmed-meshheading:19304403-Genes, APC,
pubmed-meshheading:19304403-Genes, DCC,
pubmed-meshheading:19304403-Genes, ras,
pubmed-meshheading:19304403-Humans,
pubmed-meshheading:19304403-Loss of Heterozygosity,
pubmed-meshheading:19304403-Male,
pubmed-meshheading:19304403-Microsatellite Instability,
pubmed-meshheading:19304403-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:19304403-Preoperative Care,
pubmed-meshheading:19304403-Prognosis,
pubmed-meshheading:19304403-Prospective Studies,
pubmed-meshheading:19304403-Rectal Neoplasms,
pubmed-meshheading:19304403-Rectum,
pubmed-meshheading:19304403-Remission Induction
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pubmed:year |
2009
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pubmed:articleTitle |
Molecular genetic changes associated with colorectal carcinogenesis are not prognostic for tumor regression following preoperative chemoradiation of rectal carcinoma.
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pubmed:affiliation |
Department of Medicine, Saint Barnabas Medical Center, Livingston, NJ, USA. pzauber@gmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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