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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2009-5-18
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pubmed:abstractText |
Several lines of evidence implicate CD56(bright) NK cells in the pathogenesis of multiple sclerosis (MS). This proposed immunoregulatory pathway involves already established susceptibility genes such as interleukin-2 receptor alpha (IL2RA) and interleukin-7 receptor (IL7R). We therefore investigated the CD56(bright) NK cell effector molecule KIR2DL4 for its involvement in genetic susceptibility to MS in a study population of 763 cases and 967 controls. Whereas 26% of the study population has a genotype corresponding to a lack of any functional membrane-bound form of the molecule, no association of the KIR2DL4 transmembrane alleles with susceptibility to MS was observed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1872-8421
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
29
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pubmed:volume |
210
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
113-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19304328-Adult,
pubmed-meshheading:19304328-Antigens, CD56,
pubmed-meshheading:19304328-Cell Membrane,
pubmed-meshheading:19304328-DNA Mutational Analysis,
pubmed-meshheading:19304328-Female,
pubmed-meshheading:19304328-Gene Frequency,
pubmed-meshheading:19304328-Genetic Markers,
pubmed-meshheading:19304328-Genetic Predisposition to Disease,
pubmed-meshheading:19304328-Genetic Testing,
pubmed-meshheading:19304328-Genotype,
pubmed-meshheading:19304328-Humans,
pubmed-meshheading:19304328-Killer Cells, Natural,
pubmed-meshheading:19304328-Male,
pubmed-meshheading:19304328-Middle Aged,
pubmed-meshheading:19304328-Multiple Sclerosis,
pubmed-meshheading:19304328-Polymorphism, Genetic,
pubmed-meshheading:19304328-Predictive Value of Tests,
pubmed-meshheading:19304328-Receptors, KIR2DL4,
pubmed-meshheading:19304328-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
KIR2DL4 (CD158d) polymorphisms and susceptibility to multiple sclerosis.
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pubmed:affiliation |
Katholieke Universiteit Leuven, Belgium. An.Goris@med.kuleuven.be
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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