Linked Life Data

19303539

Source:http://linkedlifedata.com/resource/pubmed/id/19303539

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-3-23
pubmed:abstractText
There is a bidirectional relation between the central nervous system and the digestive tract, i.e., the brain-gut axis. Numerous data argue for a dysfunction of the brain-gut axis in the pathophysiology of irritable bowel syndrome (IBS). Visceral hypersensitivity is a marker of IBS as well as of an abnormality of the brain-gut axis. This visceral hypersensitivity is peripheral and/or central in origin and may be the consequence of digestive inflammation or an anomaly of the nociceptive message treatment at the spinal and/or supraspinal level. Stress is involved in the genesis and maintenance of IBS. Disturbances of the autonomic nervous system are observed in IBS as a consequence of brain-gut axis dysfunction. The contribution of the neurosciences, in particular brain imaging techniques, has contributed to the better understanding of IBS physiopathology. The better knowledge of brain-gut axis dysfunction has therapeutic implications, either through drugs and/or cognitive and behavioral therapies.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0399-8320
pubmed:author
pubmed:issnType
Print
pubmed:volume
33 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S48-58
pubmed:dateRevised
2010-8-17
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
[Brain-gut axis dysfunction].
pubmed:affiliation
Clinique Universitaire d'Hépato-Gastroentérologie et Stress et Interactions neuro-Digestives, Grenoble Institut des Neurosciences (GIN, Centre de Recherche INSERM U836-UJF-CEA-CHU), CHU de Grenoble, BP217, 38043 Grenoble cedex 09, France. BBonaz@chu-grenoble.fr
pubmed:publicationType
Journal Article, English Abstract