Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2009-4-10
pubmed:abstractText
Human immunodeficiency virus (HIV)-resistant commercial sex workers provide a unique opportunity to study correlates of protection associated with natural resistance to HIV infection. Emerging data from studies of these individuals and other uninfected individuals who have been exposed to HIV suggest that low levels of immune activation may contribute to protection against infection. In the present study, HIV-resistant individuals were shown to have reduced frequencies of T cells expressing the activation marker CD69. They were also found to have elevated frequencies of regulatory T (T(reg)) cells, compared with HIV-negative control individuals. By controlling levels of T cell activation, T(reg) cells may contribute to HIV resistance by minimizing the pool of cells susceptible to infection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-1899
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
199
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1318-22
pubmed:meshHeading
pubmed-meshheading:19301980-Acquired Immunodeficiency Syndrome, pubmed-meshheading:19301980-Antigens, CD, pubmed-meshheading:19301980-Antigens, CD38, pubmed-meshheading:19301980-Antigens, CD4, pubmed-meshheading:19301980-CD4-Positive T-Lymphocytes, pubmed-meshheading:19301980-CD8-Positive T-Lymphocytes, pubmed-meshheading:19301980-Female, pubmed-meshheading:19301980-Forkhead Transcription Factors, pubmed-meshheading:19301980-HIV Infections, pubmed-meshheading:19301980-HIV Seronegativity, pubmed-meshheading:19301980-HIV-1, pubmed-meshheading:19301980-HLA-DR Antigens, pubmed-meshheading:19301980-Humans, pubmed-meshheading:19301980-Immunity, Innate, pubmed-meshheading:19301980-Interleukin-2 Receptor alpha Subunit, pubmed-meshheading:19301980-Kenya, pubmed-meshheading:19301980-Lymphocyte Activation, pubmed-meshheading:19301980-Polymerase Chain Reaction, pubmed-meshheading:19301980-Prostitution, pubmed-meshheading:19301980-T-Lymphocytes, Regulatory
pubmed:year
2009
pubmed:articleTitle
Decreased immune activation in resistance to HIV-1 infection is associated with an elevated frequency of CD4(+)CD25(+)FOXP3(+) regulatory T cells.
pubmed:affiliation
Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't