| pubmed-article:1930130 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1930130 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:1930130 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:1930130 | lifeskim:mentions | umls-concept:C0225700 | lld:lifeskim |
| pubmed-article:1930130 | lifeskim:mentions | umls-concept:C0031676 | lld:lifeskim |
| pubmed-article:1930130 | lifeskim:mentions | umls-concept:C0084692 | lld:lifeskim |
| pubmed-article:1930130 | lifeskim:mentions | umls-concept:C0143146 | lld:lifeskim |
| pubmed-article:1930130 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:1930130 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1930130 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:1930130 | lifeskim:mentions | umls-concept:C0302891 | lld:lifeskim |
| pubmed-article:1930130 | pubmed:dateCreated | 1991-11-12 | lld:pubmed |
| pubmed-article:1930130 | pubmed:abstractText | The surfactant proteins SP-A and SP-D were obtained from rats given intratracheal instillation of silica. SP-D was isolated from the 33,000 g supernatant of rat bronchoalveolar lavage fluids, and we examined whether SP-D affects surfactant secretion by alveolar type II cells. Native SP-D affected neither basal secretion nor stimulated secretion by type II cells. However, native SP-D counteracted the inhibitory effect of SP-A on surfactant secretion in a concentration-dependent manner; however, SP-D failed to counteract the inhibitory effect of concanavalin A. The activity of SP-D was unaffected by inclusion of excess methyl alpha-mannoside. Excess native SP-D competed with 125I-SP-A for high-affinity binding to type II cells. Heat treatment of SP-D and antibody against SP-D both decreased SP-D activity. Butanol extraction of native SP-D was most effective at destroying SP-D activity and attenuated the ability of the protein to compete with labelled SP-A for binding to type II cells. The butanol-soluble fraction of SP-D possessed the ability to alter the inhibitory effect of SP-A to the same extent as native SP-D. Direct binding of 125I-SP-A on nitrocellulose sheets demonstrated that SP-A could bind native SP-D, but not butanol-extracted SP-D. We conclude that native SP-D alters SP-A activity in type II cells through interaction with it via SP-D-associated lipids. | lld:pubmed |
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| pubmed-article:1930130 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1930130 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1930130 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1930130 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1930130 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:1930130 | pubmed:author | pubmed-author:MurataYY | lld:pubmed |
| pubmed-article:1930130 | pubmed:author | pubmed-author:KurokiYY | lld:pubmed |
| pubmed-article:1930130 | pubmed:author | pubmed-author:AkinoTT | lld:pubmed |
| pubmed-article:1930130 | pubmed:author | pubmed-author:ShiratoriMM | lld:pubmed |
| pubmed-article:1930130 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1930130 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1930130 | pubmed:volume | 279 ( Pt 1) | lld:pubmed |
| pubmed-article:1930130 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1930130 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1930130 | pubmed:pagination | 115-9 | lld:pubmed |
| pubmed-article:1930130 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1930130 | pubmed:meshHeading | pubmed-meshheading:1930130-... | lld:pubmed |
| pubmed-article:1930130 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1930130 | pubmed:articleTitle | Surfactant protein D (SP-D) counteracts the inhibitory effect of surfactant protein A (SP-A) on phospholipid secretion by alveolar type II cells. Interaction of native SP-D with SP-A. | lld:pubmed |
| pubmed-article:1930130 | pubmed:affiliation | Department of Biochemistry, Sapporo Medical College, Japan. | lld:pubmed |
| pubmed-article:1930130 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1930130 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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