Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2009-8-19
pubmed:abstractText
The goal of this study was to analyze results and to determine factors affecting outcome of HLA-matched hematopoetic stem cells transplantation (MRD-HSCT) for patients with acute leukemia transplanted in first complete remission in Eastern European countries. Six hundred forty HSCT were performed between 1990 and 2006 for adults with acute myeloid (n = 459) and lymphoblastic (n = 181) leukemia. Two-year leukemia-free survival (LFS), nonrelapse mortality (NRM), and relapse incidence were 58 +/- 2%, 19 +/- 2%, and 23 +/- 2%, respectively. The cumulative incidence of NRM decreased from 22 +/- 2% for patients treated between 1990 and 2002 to 15 +/- 3% for transplantations performed between 2003 and 2006 (p = 0.02), despite increasing recipient age. In a multivariate analysis, time of HSCT affected both NRM and LFS. Among other prognostic factors, the use of TBI decreased relapse incidence and increased the LFS rate. We conclude that results of MRD-HSCT for acute leukemia in Eastern Europe improved over time as a consequence of decreased NRM. The use of TBI containing regimens appears advantagous.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1432-0584
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
88
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1005-13
pubmed:meshHeading
pubmed-meshheading:19301005-Adolescent, pubmed-meshheading:19301005-Adult, pubmed-meshheading:19301005-Aged, pubmed-meshheading:19301005-Europe, Eastern, pubmed-meshheading:19301005-HLA Antigens, pubmed-meshheading:19301005-Hematopoietic Stem Cell Transplantation, pubmed-meshheading:19301005-Histocompatibility, pubmed-meshheading:19301005-Humans, pubmed-meshheading:19301005-Leukemia, pubmed-meshheading:19301005-Leukemia, Myeloid, Acute, pubmed-meshheading:19301005-Middle Aged, pubmed-meshheading:19301005-Precursor Cell Lymphoblastic Leukemia-Lymphoma, pubmed-meshheading:19301005-Prognosis, pubmed-meshheading:19301005-Recurrence, pubmed-meshheading:19301005-Remission Induction, pubmed-meshheading:19301005-Retrospective Studies, pubmed-meshheading:19301005-Survival Analysis, pubmed-meshheading:19301005-Time Factors, pubmed-meshheading:19301005-Transplantation, Homologous, pubmed-meshheading:19301005-Treatment Outcome, pubmed-meshheading:19301005-Whole-Body Irradiation, pubmed-meshheading:19301005-Young Adult
pubmed:year
2009
pubmed:articleTitle
Outcome of HLA-matched related allogeneic hematopoietic stem cell transplantation for patients with acute leukemia in first complete remission treated in Eastern European centers. Better results in recent years.
pubmed:affiliation
Department of Clinical Oncology, Comprehensive Cancer Center, Maria Sklodowska-Curie Memorial Institute Branch Gliwice, Wybrzeze Armii Krajowej 15, 44-101, Gliwice, Poland. sgiebel@poczta.onet.pl
pubmed:publicationType
Journal Article, Multicenter Study