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rdf:type |
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lifeskim:mentions |
umls-concept:C0015852,
umls-concept:C0024432,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0087066,
umls-concept:C0204727,
umls-concept:C0205409,
umls-concept:C0205460,
umls-concept:C0230704,
umls-concept:C0243077,
umls-concept:C0871161,
umls-concept:C1522492,
umls-concept:C1661291
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pubmed:issue |
4
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pubmed:dateCreated |
2009-4-28
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pubmed:abstractText |
New compounds designated pentacecilides A to C were isolated from the fermentation broth of Penicillium cecidicola FKI-3765-1 by solvent extraction, silica gel column chromatography and preparative HPLC. Pentacecilides A and B dose-dependently inhibited lipid droplet formation in mouse macrophages. Furthermore, pentacecilides A and B were found to inhibit the synthesis of cholesteryl ester in mouse macrophages with respective IC(50) values of 3.65 and 4.76 microM without any cytotoxic effect, but pentacecilide C showed almost no activity. The study of the mechanism of action strongly suggested that pentacecilides A and B inhibit acyl-CoA: cholesterol acyltransferase activity in macrophages.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0021-8820
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
195-200
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19300470-Animals,
pubmed-meshheading:19300470-CHO Cells,
pubmed-meshheading:19300470-Cholesterol,
pubmed-meshheading:19300470-Cholesterol Esters,
pubmed-meshheading:19300470-Chromatography, High Pressure Liquid,
pubmed-meshheading:19300470-Cricetinae,
pubmed-meshheading:19300470-Cricetulus,
pubmed-meshheading:19300470-Culture Media,
pubmed-meshheading:19300470-Fermentation,
pubmed-meshheading:19300470-Hypolipidemic Agents,
pubmed-meshheading:19300470-Lipid Metabolism,
pubmed-meshheading:19300470-Lysosomes,
pubmed-meshheading:19300470-Macrophages, Peritoneal,
pubmed-meshheading:19300470-Mice,
pubmed-meshheading:19300470-Penicillium,
pubmed-meshheading:19300470-Sesquiterpenes,
pubmed-meshheading:19300470-Spectrophotometry, Ultraviolet,
pubmed-meshheading:19300470-Sterol O-Acyltransferase
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pubmed:year |
2009
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pubmed:articleTitle |
Pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages, produced by Penicillium cecidicola FKI-3765-1: I. Taxonomy, fermentation, isolation and biological properties.
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pubmed:affiliation |
Graduate School of Pharmaceutical Sciences, Kitasato University, Shirokane, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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