Linked Life Data

19298834

Source:http://linkedlifedata.com/resource/pubmed/id/19298834

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:19298834rdf:typepubmed:Citationlld:pubmed
pubmed-article:19298834lifeskim:mentionsumls-concept:C1123023lld:lifeskim
pubmed-article:19298834lifeskim:mentionsumls-concept:C0425359lld:lifeskim
pubmed-article:19298834lifeskim:mentionsumls-concept:C0034650lld:lifeskim
pubmed-article:19298834lifeskim:mentionsumls-concept:C0327029lld:lifeskim
pubmed-article:19298834lifeskim:mentionsumls-concept:C0999016lld:lifeskim
pubmed-article:19298834lifeskim:mentionsumls-concept:C0036536lld:lifeskim
pubmed-article:19298834lifeskim:mentionsumls-concept:C0036537lld:lifeskim
pubmed-article:19298834lifeskim:mentionsumls-concept:C0017890lld:lifeskim
pubmed-article:19298834lifeskim:mentionsumls-concept:C0030956lld:lifeskim
pubmed-article:19298834lifeskim:mentionsumls-concept:C0205409lld:lifeskim
pubmed-article:19298834lifeskim:mentionsumls-concept:C1136254lld:lifeskim
pubmed-article:19298834pubmed:issue1lld:pubmed
pubmed-article:19298834pubmed:dateCreated2009-5-18lld:pubmed
pubmed-article:19298834pubmed:abstractTextAntimicrobial peptides are components of innate immunity that is the first-line defense against invading pathogens for a wide range of organisms. Here, we describe the isolation, biological characterization and amino acid sequencing of a novel neutral Glycine/Leucine-rich antimicrobial peptide from skin secretion of Leptodactylus pentadactylus named leptoglycin. The amino acid sequence of the peptide purified by RP-HPLC (C(18) column) was deduced by mass spectrometric de novo sequencing and confirmed by Edman degradation: GLLGGLLGPLLGGGGGGGGGLL. Leptoglycin was able to inhibit the growth of Gram-negative bacteria Pseudomonas aeruginosa, Escherichia coli and Citrobacter freundii with minimal inhibitory concentrations (MICs) of 8 microM, 50 microM, and 75 microM respectively, but it did not show antimicrobial activity against Gram-positive bacteria (Staphylococcus aureus, Micrococcus luteus and Enterococcus faecalis), yeasts (Candida albicans and Candida tropicalis) and dermatophytes fungi (Microsporum canis and Trichophyton rubrum). No hemolytic activity was observed at the 2-200 microM range concentration. The amino acid sequence of leptoglycin with high level of glycine (59.1%) and leucine (36.4%) containing an unusual central proline suggests the existence of a new class of Gly/Leu-rich antimicrobial peptides. Taken together, these results suggest that this natural antimicrobial peptide could be a tool to develop new antibiotics.lld:pubmed
pubmed-article:19298834pubmed:languageenglld:pubmed
pubmed-article:19298834pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19298834pubmed:citationSubsetIMlld:pubmed
pubmed-article:19298834pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19298834pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19298834pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19298834pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19298834pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19298834pubmed:statusMEDLINElld:pubmed
pubmed-article:19298834pubmed:monthJullld:pubmed
pubmed-article:19298834pubmed:issn1879-3150lld:pubmed
pubmed-article:19298834pubmed:authorpubmed-author:KonnoKatsuhir...lld:pubmed
pubmed-article:19298834pubmed:authorpubmed-author:PimentaDaniel...lld:pubmed
pubmed-article:19298834pubmed:authorpubmed-author:RichardsonMic...lld:pubmed
pubmed-article:19298834pubmed:authorpubmed-author:RochaMarcos...lld:pubmed
pubmed-article:19298834pubmed:authorpubmed-author:CardiBruno...lld:pubmed
pubmed-article:19298834pubmed:authorpubmed-author:CarvalhoKrish...lld:pubmed
pubmed-article:19298834pubmed:authorpubmed-author:SousaJuliana...lld:pubmed
pubmed-article:19298834pubmed:authorpubmed-author:BertoRaquel...lld:pubmed
pubmed-article:19298834pubmed:authorpubmed-author:GoisElicélia...lld:pubmed
pubmed-article:19298834pubmed:authorpubmed-author:Fontenele-Car...lld:pubmed
pubmed-article:19298834pubmed:authorpubmed-author:HonórioJosé...lld:pubmed
pubmed-article:19298834pubmed:authorpubmed-author:CamargoAntôni...lld:pubmed
pubmed-article:19298834pubmed:issnTypeElectroniclld:pubmed
pubmed-article:19298834pubmed:volume54lld:pubmed
pubmed-article:19298834pubmed:ownerNLMlld:pubmed
pubmed-article:19298834pubmed:authorsCompleteYlld:pubmed
pubmed-article:19298834pubmed:pagination23-32lld:pubmed
pubmed-article:19298834pubmed:meshHeadingpubmed-meshheading:19298834...lld:pubmed
pubmed-article:19298834pubmed:meshHeadingpubmed-meshheading:19298834...lld:pubmed
pubmed-article:19298834pubmed:meshHeadingpubmed-meshheading:19298834...lld:pubmed
pubmed-article:19298834pubmed:meshHeadingpubmed-meshheading:19298834...lld:pubmed
pubmed-article:19298834pubmed:meshHeadingpubmed-meshheading:19298834...lld:pubmed
pubmed-article:19298834pubmed:meshHeadingpubmed-meshheading:19298834...lld:pubmed
pubmed-article:19298834pubmed:meshHeadingpubmed-meshheading:19298834...lld:pubmed
pubmed-article:19298834pubmed:meshHeadingpubmed-meshheading:19298834...lld:pubmed
pubmed-article:19298834pubmed:meshHeadingpubmed-meshheading:19298834...lld:pubmed
pubmed-article:19298834pubmed:meshHeadingpubmed-meshheading:19298834...lld:pubmed
pubmed-article:19298834pubmed:meshHeadingpubmed-meshheading:19298834...lld:pubmed
pubmed-article:19298834pubmed:meshHeadingpubmed-meshheading:19298834...lld:pubmed
pubmed-article:19298834pubmed:meshHeadingpubmed-meshheading:19298834...lld:pubmed
pubmed-article:19298834pubmed:meshHeadingpubmed-meshheading:19298834...lld:pubmed
pubmed-article:19298834pubmed:meshHeadingpubmed-meshheading:19298834...lld:pubmed
pubmed-article:19298834pubmed:meshHeadingpubmed-meshheading:19298834...lld:pubmed
pubmed-article:19298834pubmed:meshHeadingpubmed-meshheading:19298834...lld:pubmed
pubmed-article:19298834pubmed:meshHeadingpubmed-meshheading:19298834...lld:pubmed
pubmed-article:19298834pubmed:meshHeadingpubmed-meshheading:19298834...lld:pubmed
pubmed-article:19298834pubmed:year2009lld:pubmed
pubmed-article:19298834pubmed:articleTitleLeptoglycin: a new Glycine/Leucine-rich antimicrobial peptide isolated from the skin secretion of the South American frog Leptodactylus pentadactylus (Leptodactylidae).lld:pubmed
pubmed-article:19298834pubmed:affiliationLaboratório de Toxinologia e Farmacologia Molecular, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, CE 60.740-000, Brazil.lld:pubmed
pubmed-article:19298834pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19298834pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed