Linked Life Data

1929868

Source:http://linkedlifedata.com/resource/pubmed/id/1929868

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1991-11-18
pubmed:abstractText
In order to investigate chloroquine retinopathy, the effect of chloroquine on the viability and differentiation of primary cell cultures of embryonic chick neuronal retina, retinal pigment epithelium (RPE), brain and meninges were investigated. The sensitivity of the cells, measured as reduction of viability, showed the following order: RPE greater than brain greater than meninges greater than neuronal retina. The human serum chloroquine concentration range which leads to ocular damage in vivo was identical to the concentration range in the culture medium which affected RPE viability. In addition, the differentiation of nerve cells in brain cell cultures was affected at much lower chloroquine concentrations than astroglia cells or nerve cells in neuronal retina cell cultures. Some possible mechanisms for chloroquine retinopathy were assessed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0340-5761
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
480-4
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Neurotoxic effects of chloroquine in vitro.
pubmed:affiliation
Institute of Toxicology, Swiss Federal Institute of Technology.
pubmed:publicationType
Journal Article