Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-6-2
pubmed:abstractText
Accumulation of fatty acids and neutral lipids in nonadipose tissues is cytotoxic. We recently showed that ERBB2-positive breast cancer cells produce significantly high amounts of fats, because of overexpression of the peroxisome proliferator-activated receptor (PPAR)gamma-binding protein and the nuclear receptor NR1D1 (nuclear receptor subfamily 1, group D, member 1; Rev-erbalpha). These genes upregulate de novo fatty acid synthesis, which is a critical pathway for the energy production and survival of these cells. NR1D1 and PPARgamma-binding protein are functionally related to PPARgamma, a well established positive regulator of adipogenesis and lipid storage.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-10529898, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-10555139, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-11103797, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-11278654, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-11473037, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-12007739, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-12186376, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-12629214, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-12684033, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-12805375, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-12821652, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-12840659, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-13428781, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-14725507, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-14743203, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-15235125, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-15607569, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-15901996, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-16264182, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-16380219, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-16406575, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-16982728, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-17134676, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-17157792, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-17168666, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-17848638, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-17882277, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-3798106, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-9254064, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-9325263, http://linkedlifedata.com/resource/pubmed/commentcorrection/19298655-9829981
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1465-542X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R16
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Peroxisome proliferator-activated receptor-gamma protects ERBB2-positive breast cancer cells from palmitate toxicity.
pubmed:affiliation
Department of Biomedical Sciences, Gen*NY*Sis Center for Excellence in Cancer Genomics, University at Albany, Rensselaer, NY 12144, USA. akourtidis@albany.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't