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pubmed-article:19297741pubmed:abstractTextWe further support the notion that the catechol-O-methyltransferase (COMT) polymorphism may play a role in cognitive function. A continuous visual 3-back numerical working memory task was performed for an hour among 21 patients with different COMT genotypes. P300 visual event-related potentials evoked from the 3-back task were first utilized to observe the relationship between this COMT polymorphism and cortical physiology. The results showed that Val/Met heterozygous individuals show poorer performance, lower P300 amplitude, and higher P300 latency than those bearing the Val/Val homozygote on the task. This visual 3-back paradigm is a promising tool to examine continuous working memory capacity. The role of the COMT gene in dopamine catabolism makes for the influence of COMT polymorphism on P300 endophenotypes.lld:pubmed
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pubmed-article:19297741pubmed:articleTitleComparison of visual evoked-related potentials in healthy young adults of different catechol-O-methyltransferase genotypes in a continuous 3-back task.lld:pubmed
pubmed-article:19297741pubmed:affiliationInstitute of Biomedical Engineering, West China Medical Center, SichuanUniversity, Chengdu, China.lld:pubmed
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