Linked Life Data

19297741

Source:http://linkedlifedata.com/resource/pubmed/id/19297741

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-3-18
pubmed:abstractText
We further support the notion that the catechol-O-methyltransferase (COMT) polymorphism may play a role in cognitive function. A continuous visual 3-back numerical working memory task was performed for an hour among 21 patients with different COMT genotypes. P300 visual event-related potentials evoked from the 3-back task were first utilized to observe the relationship between this COMT polymorphism and cortical physiology. The results showed that Val/Met heterozygous individuals show poorer performance, lower P300 amplitude, and higher P300 latency than those bearing the Val/Val homozygote on the task. This visual 3-back paradigm is a promising tool to examine continuous working memory capacity. The role of the COMT gene in dopamine catabolism makes for the influence of COMT polymorphism on P300 endophenotypes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1473-558X
pubmed:author
pubmed:issnType
Electronic
pubmed:day
25
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
521-4
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Comparison of visual evoked-related potentials in healthy young adults of different catechol-O-methyltransferase genotypes in a continuous 3-back task.
pubmed:affiliation
Institute of Biomedical Engineering, West China Medical Center, SichuanUniversity, Chengdu, China.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't