Linked Life Data

19294514

Source:http://linkedlifedata.com/resource/pubmed/id/19294514

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-7-10
pubmed:abstractText
Alternatives for ossicular replacements were fabricated in order to overcome persisting rejections in middle ear prosthetization. Unlike the synthetic prostheses in fashion, we propose biological and biohybrid replacements containing extra cellular matrix (ECM) molecules to improve biointegration. In this study, ECM-containing devices shaped as Partial Ossicular Replacement Prostheses (PORPs) were fabricated reproducing the current synthetic models. Biological PORPs were obtained from human decellularized cortical bone allografts by computer numerically controlled ultraprecision micromilling. Moreover, porous PORP-like scaffolds were produced and cultured with osteoinduced human mesenchymal stromal cells to generate in vitro bone ECM within the scaffold porosity (biohybrid PORPs). The acoustic responses of such devices were investigated and compared to those of commercial prostheses. Results showed that biological PORPs transmit mechanical signals with appropriate frequencies, amplitudes, and with early extinction time. Although signal transmission in biohybrid PORPs showed insufficient amplitude, we believe that tissue engineered constructs represent the new challenge in ossiculoplasty.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1572-8781
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
783-93
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Novel biological/biohybrid prostheses for the ossicular chain: fabrication feasibility and preliminary functional characterization.
pubmed:affiliation
CUCCS/RRMR (Centro per l'Uso Clinico delle Cellule Staminali/Rete Regionale di Medicina Rigenerativa), University of Pisa, via Roma 55, 56126 Pisa, Italy. s.danti@med.unipi.it
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't