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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-4-3
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pubmed:abstractText |
AMPK (AMP-activated protein kinase) is highly conserved in eukaryotes, where it functions primarily as a sensor of cellular energy status. Recent studies indicate that AMPK activation strongly suppresses cell proliferation in non-malignant cells as well as in tumor cells. In this study, quercetin activated AMPK in MCF breast cancer cell lines and HT-29 colon cancer cells, and this activation of AMPK seemed to be closely related to a decrease in COX-2 expression. The application of a COX-2 inhibitor or cox-2-/- cells supported the idea that AMPK is an upstream signal of COX-2, and is required for the anti-proliferatory and pro-apoptotic effects of quercetin. The suppressive or growth inhibitory effects of quercetin on COX-2 were abolished by treating cancer cells with an AMPK inhibitor Compound C. These results suggest that AMPK is crucial to the anti-cancer effect of quercetin and that the AMPK-COX-2 signaling pathway is important in quercetin-mediated cancer control.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19293639-10874062,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19293639-18716159
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1226-3613
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
31
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
201-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:19293639-AMP-Activated Protein Kinases,
pubmed-meshheading:19293639-Anticarcinogenic Agents,
pubmed-meshheading:19293639-Antioxidants,
pubmed-meshheading:19293639-Apoptosis,
pubmed-meshheading:19293639-Cell Cycle,
pubmed-meshheading:19293639-Cell Line, Tumor,
pubmed-meshheading:19293639-Cell Proliferation,
pubmed-meshheading:19293639-Cyclooxygenase 2,
pubmed-meshheading:19293639-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:19293639-Enzyme Activation,
pubmed-meshheading:19293639-Humans,
pubmed-meshheading:19293639-Pyrazoles,
pubmed-meshheading:19293639-Pyrimidines,
pubmed-meshheading:19293639-Quercetin
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pubmed:year |
2009
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pubmed:articleTitle |
AMP kinase/cyclooxygenase-2 pathway regulates proliferation and apoptosis of cancer cells treated with quercetin.
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pubmed:affiliation |
Department of Food and Nutrition, Hannam University Daedeok Valley Campus, Daejeon 305-811, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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