Linked Life Data

1929342

Source:http://linkedlifedata.com/resource/pubmed/id/1929342

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1991-11-1
pubmed:abstractText
The efficacies of 40 mg of ofloxacin per kg/day given orally and 250 mg of penicillin per kg/day given intramuscularly, alone or in combination, were evaluated in the prevention of mortality of C3H/HeN female mice given 8.2 Gy of 60Co radiation. Mortalities were 51 of 60 mice (85%) in the control group, 46 of 60 mice (77%) among those treated with penicillin, 32 of 60 mice (53%) among those treated with ofloxacin (P less than 0.05), and 5 of 60 mice (8%) among those treated with ofloxacin and penicillin (P less than 0.001). The organisms recovered from the livers of control mice were members of the family Enterobacteriaceae and Streptococcus spp. A reduction in the number of the Enterobacteriaceae was noted only in ofloxacin-treated mice, and a reduction in the number of Streptococcus spp. was noted only in the penicillin-treated mice. Reductions in the numbers of both groups of organisms were noted only in the animals treated with both agents. This study shows the advantage of the combination of ofloxacin and penicillin in the prevention of bacterial translocation and animal mortality after irradiation.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1685-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Ofloxacin and penicillin G combination therapy in prevention of bacterial translocation and animal mortality after irradiation.
pubmed:affiliation
Experimental Hematology Department, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20889-5145.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.