| pubmed-article:19293003 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19293003 | lifeskim:mentions | umls-concept:C0028128 | lld:lifeskim |
| pubmed-article:19293003 | lifeskim:mentions | umls-concept:C0012472 | lld:lifeskim |
| pubmed-article:19293003 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:19293003 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:19293003 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:19293003 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:19293003 | lifeskim:mentions | umls-concept:C1370600 | lld:lifeskim |
| pubmed-article:19293003 | lifeskim:mentions | umls-concept:C1327413 | lld:lifeskim |
| pubmed-article:19293003 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:19293003 | lifeskim:mentions | umls-concept:C0764565 | lld:lifeskim |
| pubmed-article:19293003 | pubmed:issue | 7-8 | lld:pubmed |
| pubmed-article:19293003 | pubmed:dateCreated | 2009-6-1 | lld:pubmed |
| pubmed-article:19293003 | pubmed:abstractText | Valnemulin is a pleuromutilin antibiotic used in clinics for the treatment of various infections. We studied the in vitro anti-inflammatory effects of valnemulin and associated signal transduction mechanisms in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. We found that valnemulin inhibited nitric oxide (NO), prostaglandin E2 (PGE2), tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), and increased interleukin-10 (IL-10) production. Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expression were also inhibited by valnemulin. We further observed that valnemulin prevented the LPS-induced NF-kappaB translocation from the cytoplasm into the nucleus. Valnemulin also blocked phosphorylation of three mitogen-activated protein kinases (MAPKs): extracellular signal receptor-activated kinase (ERK) 1/2, p38, and c-Jun N-terminal kinase (JNK). Our data indicate that valnemulin may have therapeutic anti-inflammatory effects independent of its antibacterial activity. | lld:pubmed |
| pubmed-article:19293003 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19293003 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19293003 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19293003 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19293003 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19293003 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19293003 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19293003 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19293003 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19293003 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19293003 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19293003 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19293003 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19293003 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19293003 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19293003 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:19293003 | pubmed:issn | 1878-1705 | lld:pubmed |
| pubmed-article:19293003 | pubmed:author | pubmed-author:DIKF MFM | lld:pubmed |
| pubmed-article:19293003 | pubmed:author | pubmed-author:ZhangLeiL | lld:pubmed |
| pubmed-article:19293003 | pubmed:author | pubmed-author:YuSongS | lld:pubmed |
| pubmed-article:19293003 | pubmed:author | pubmed-author:ZhangXuemeiX | lld:pubmed |
| pubmed-article:19293003 | pubmed:author | pubmed-author:LiHongyuH | lld:pubmed |
| pubmed-article:19293003 | pubmed:author | pubmed-author:DengXumingX | lld:pubmed |
| pubmed-article:19293003 | pubmed:author | pubmed-author:FengHaihuaH | lld:pubmed |
| pubmed-article:19293003 | pubmed:author | pubmed-author:XiongHuanzhan... | lld:pubmed |
| pubmed-article:19293003 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19293003 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:19293003 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19293003 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19293003 | pubmed:pagination | 810-6 | lld:pubmed |
| pubmed-article:19293003 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:19293003 | pubmed:meshHeading | pubmed-meshheading:19293003... | lld:pubmed |
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| pubmed-article:19293003 | pubmed:meshHeading | pubmed-meshheading:19293003... | lld:pubmed |
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| pubmed-article:19293003 | pubmed:meshHeading | pubmed-meshheading:19293003... | lld:pubmed |
| pubmed-article:19293003 | pubmed:meshHeading | pubmed-meshheading:19293003... | lld:pubmed |
| pubmed-article:19293003 | pubmed:meshHeading | pubmed-meshheading:19293003... | lld:pubmed |
| pubmed-article:19293003 | pubmed:meshHeading | pubmed-meshheading:19293003... | lld:pubmed |
| pubmed-article:19293003 | pubmed:meshHeading | pubmed-meshheading:19293003... | lld:pubmed |
| pubmed-article:19293003 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19293003 | pubmed:articleTitle | Valnemulin downregulates nitric oxide, prostaglandin E2, and cytokine production via inhibition of NF-kappaB and MAPK activity. | lld:pubmed |
| pubmed-article:19293003 | pubmed:affiliation | Institute of Zoonoses, College of Animal Science and Veterinary Medicine, Jilin University, Changchun, Jilin 130062, China. | lld:pubmed |
| pubmed-article:19293003 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19293003 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
