Linked Life Data

1929189

Source:http://linkedlifedata.com/resource/pubmed/id/1929189

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1991-11-13
pubmed:abstractText
Immunosuppression with Cyclosporin A has resulted in dramatic improvements in the results of cadaveric kidney transplantation in Singapore. However, its major limitation is its nephrotoxicity which can appear in various forms after transplantation including a delay in graft function and chronic renal dysfunction. The clinical course of two patients with initial function but delayed onset of acute functional Cyclosporine nephrotoxicity are described. Recovery was documented in both cases with reduction of Cyclosporine dosage. A decline in renal blood flow and increase in renal vascular resistance is likely to have played a role in the pathogenesis of the acute functional nephrotoxicity. Cyclosporine induced imbalance in Prostaglandin synthesis within the kidney has been implicated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0304-4602
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
403-6
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Acute cyclosporin A induced nephrotoxicity in renal allografts.
pubmed:affiliation
Department of Renal Medicine, Singapore General Hospital.
pubmed:publicationType
Journal Article, Case Reports