Linked Life Data

19290371

Source:http://linkedlifedata.com/resource/pubmed/id/19290371

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
2009-3-17
pubmed:abstractText
Five binuclear Schiff base copper(ii) complexes [Cu(2)(L)(OAc)].3DMF (), [Cu(2)(L)(OAc)](2).3DMF (), [Cu(2)(L)(BNPP)].3CH(3)CN (), [Cu(2)(L)(Fa)].2DMF () and [Cu(2)(L)(Pa)].DMF () (H(3)L = N,N'-bis(3,5-tert-butylsalicylidene-2-hydroxy)-1,3-propanediamine, OAc = acetic acid, BNPP = bis(4-nitrophenyl)phosphate, Fa = 2-tetrahydrofuroic acid, Pa = benzoic acid) have been synthesized and characterized by X-ray single-crystal structure analysis. Variable-temperature magnetic susceptibility studies (2-300 K) indicate the existence of ferromagnetic coupling between the copper(ii) ions in complexes and , and antiferromagnetic coupling in complexes and . The interaction of these complexes with CT-DNA has been studied by using absorption and emission spectral methods. The apparent binding constant (K(app)) values for complexes , , and are 4.67 x 10(5), 9.48 x 10(5), 4.30 x 10(5) and 3.90 x 10(5) M(-1), respectively, which show that the complexes bind to DNA by moderate intercalative binding modes. Furthermore, all these complexes can cleave plasmid DNA to nicked DNA in a sequential manner as the concentrations or reaction times are increased in the absence of reducing agent. Their cleavage activities are promoted in the presence of hydrogen peroxide. The cleavage mechanisms between the complexes and plasmid DNA are likely to involve singlet oxygen (1)O(2) and OH as reactive oxygen species.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1477-9226
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2374-82
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Synthesis, structure, magnetic properties and DNA cleavage of binuclear Cu(II) Schiff-base complexes.
pubmed:affiliation
Department of Chemistry, Nankai University, Weijin Road 94, Tianjin, 300071, People's Republic of China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't