Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1991-11-1
|
| pubmed:abstractText |
To determine if n-of-1 randomized controlled trials (n-of-1 RCT) are useful in the care of patients with nonreversible chronic airflow limitation (CAL). Individual trials had a double-blind, randomized, multiple crossover design. Patients with CAL were recruited from several respirology practices. For each individual trial the main outcome measure was a symptom questionnaire; peak flow measurements were used as a secondary measure. Physicians' plans of management (before and after trials) and confidence in the plans were determined. The proportion of trials that provided a definite clinical or statistical answer was established. Patients were followed, and long-term adherence to decisions based on n-of-1 RCT was examined. A total of 26 n-of-1 RCT in patients with CAL were attempted; 18 of these (69%) were completed. After 17 (94%) of the completed trials clinicians expressed a high degree of confidence in their management plans, confidence that was not, in any case, present before the trial. After 8 n-of-1 RCT (44% of all completed, or 31% of all trials) clinicians decided to stop the drug, which would otherwise have been continued indefinitely. In all 17 of the clinically definite n-of-1 RCT, the management decision that followed the trial was still being adhered to 40 months (on average) after completion of the trial. The results support the feasibility and usefulness of n-of-1 RCT in respirology practice.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0003-0805
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
144
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
962-4
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1928975-Double-Blind Method,
pubmed-meshheading:1928975-Evaluation Studies as Topic,
pubmed-meshheading:1928975-Humans,
pubmed-meshheading:1928975-Lung Diseases, Obstructive,
pubmed-meshheading:1928975-Questionnaires,
pubmed-meshheading:1928975-Randomized Controlled Trials as Topic,
pubmed-meshheading:1928975-Research Design,
pubmed-meshheading:1928975-Respiratory Function Tests
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Clinical usefulness of n-of-1 randomized controlled trials in patients with nonreversible chronic airflow limitation.
|
| pubmed:affiliation |
Department of Medicine, St. Joseph's Hospital, Hamilton, Ontario, Canada.
|
| pubmed:publicationType |
Journal Article
|