Linked Life Data

19289124

Source:http://linkedlifedata.com/resource/pubmed/id/19289124

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2009-5-25
pubmed:abstractText
The recent recognition of new types of cell-cell communication pathways challenges classic theories of cell autonomy. Evidence of functional "proteome mixing" among interacting cells, particularly immune cells, supports the notion that no cell is an island, and that even these "unsplittable" units are actually non-autonomous. We summarize various mechanisms of intercellular transfer of proteins--trans-endocytosis, trogocytosis, exosomal transport, shuttle through nanotubes, and cell-contact-dependent intercellular transfer of intracellular proteins including oncogenic Ras. These phenomena suggest exciting new possibilities for proteome research, focusing on system-level proteomics that characterize cell contents and functions in the context of intercellular protein transfer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1873-3468
pubmed:author
pubmed:issnType
Electronic
pubmed:day
5
pubmed:volume
583
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1792-9
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Intercellular exchange of proteins: the immune cell habit of sharing.
pubmed:affiliation
Department of Neurobiology, The George S. Wise Faculty of Life Sciences, Tel-Aviv University, 69978 Tel-Aviv, Israel.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't