| pubmed-article:19289085 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19289085 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:19289085 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:19289085 | lifeskim:mentions | umls-concept:C1283994 | lld:lifeskim |
| pubmed-article:19289085 | lifeskim:mentions | umls-concept:C1179435 | lld:lifeskim |
| pubmed-article:19289085 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:19289085 | lifeskim:mentions | umls-concept:C1420682 | lld:lifeskim |
| pubmed-article:19289085 | lifeskim:mentions | umls-concept:C2752244 | lld:lifeskim |
| pubmed-article:19289085 | lifeskim:mentions | umls-concept:C1705248 | lld:lifeskim |
| pubmed-article:19289085 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:19289085 | lifeskim:mentions | umls-concept:C1548799 | lld:lifeskim |
| pubmed-article:19289085 | lifeskim:mentions | umls-concept:C1524073 | lld:lifeskim |
| pubmed-article:19289085 | lifeskim:mentions | umls-concept:C0449432 | lld:lifeskim |
| pubmed-article:19289085 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:19289085 | pubmed:dateCreated | 2009-3-17 | lld:pubmed |
| pubmed-article:19289085 | pubmed:abstractText | Outside cells of the preimplantation mouse embryo form the trophectoderm (TE), a process requiring the transcription factor Tead4. Here, we show that transcriptionally active Tead4 can induce Cdx2 and other trophoblast genes in parallel in embryonic stem cells. In embryos, the Tead4 coactivator protein Yap localizes to nuclei of outside cells, and modulation of Tead4 or Yap activity leads to changes in Cdx2 expression. In inside cells, Yap is phosphorylated and cytoplasmic, and this involves the Hippo signaling pathway component Lats. We propose that active Tead4 promotes TE development in outside cells, whereas Tead4 activity is suppressed in inside cells by cell contact- and Lats-mediated inhibition of nuclear Yap localization. Thus, differential signaling between inside and outside cell populations leads to changes in cell fate specification during TE formation. | lld:pubmed |
| pubmed-article:19289085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19289085 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19289085 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19289085 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19289085 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19289085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19289085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19289085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19289085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19289085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19289085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19289085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19289085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19289085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19289085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19289085 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19289085 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19289085 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:19289085 | pubmed:issn | 1878-1551 | lld:pubmed |
| pubmed-article:19289085 | pubmed:author | pubmed-author:SasakiHiroshi... | lld:pubmed |
| pubmed-article:19289085 | pubmed:author | pubmed-author:OgonukiNarumi... | lld:pubmed |
| pubmed-article:19289085 | pubmed:author | pubmed-author:RossantJanetJ | lld:pubmed |
| pubmed-article:19289085 | pubmed:author | pubmed-author:NiwaHitoshiH | lld:pubmed |
| pubmed-article:19289085 | pubmed:author | pubmed-author:NojimaHiroshi... | lld:pubmed |
| pubmed-article:19289085 | pubmed:author | pubmed-author:KuriharaHirok... | lld:pubmed |
| pubmed-article:19289085 | pubmed:author | pubmed-author:NakaoKazukiK | lld:pubmed |
| pubmed-article:19289085 | pubmed:author | pubmed-author:Morin-Kensick... | lld:pubmed |
| pubmed-article:19289085 | pubmed:author | pubmed-author:OtaMitsunoriM | lld:pubmed |
| pubmed-article:19289085 | pubmed:author | pubmed-author:MakitaRyosuke... | lld:pubmed |
| pubmed-article:19289085 | pubmed:author | pubmed-author:InoueKen-ichi... | lld:pubmed |
| pubmed-article:19289085 | pubmed:author | pubmed-author:NishiokaNoriy... | lld:pubmed |
| pubmed-article:19289085 | pubmed:author | pubmed-author:YabutaNorikaz... | lld:pubmed |
| pubmed-article:19289085 | pubmed:author | pubmed-author:KiyonariHiros... | lld:pubmed |
| pubmed-article:19289085 | pubmed:author | pubmed-author:HiraharaShino... | lld:pubmed |
| pubmed-article:19289085 | pubmed:author | pubmed-author:StephensonRob... | lld:pubmed |
| pubmed-article:19289085 | pubmed:author | pubmed-author:RalstonAmyA | lld:pubmed |
| pubmed-article:19289085 | pubmed:author | pubmed-author:AdachiKenjiro... | lld:pubmed |
| pubmed-article:19289085 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19289085 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:19289085 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19289085 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19289085 | pubmed:pagination | 398-410 | lld:pubmed |
| pubmed-article:19289085 | pubmed:dateRevised | 2011-4-22 | lld:pubmed |
| pubmed-article:19289085 | pubmed:meshHeading | pubmed-meshheading:19289085... | lld:pubmed |
| pubmed-article:19289085 | pubmed:meshHeading | pubmed-meshheading:19289085... | lld:pubmed |
| pubmed-article:19289085 | pubmed:meshHeading | pubmed-meshheading:19289085... | lld:pubmed |
| pubmed-article:19289085 | pubmed:meshHeading | pubmed-meshheading:19289085... | lld:pubmed |
| pubmed-article:19289085 | pubmed:meshHeading | pubmed-meshheading:19289085... | lld:pubmed |
| pubmed-article:19289085 | pubmed:meshHeading | pubmed-meshheading:19289085... | lld:pubmed |
| pubmed-article:19289085 | pubmed:meshHeading | pubmed-meshheading:19289085... | lld:pubmed |
| pubmed-article:19289085 | pubmed:meshHeading | pubmed-meshheading:19289085... | lld:pubmed |
| pubmed-article:19289085 | pubmed:meshHeading | pubmed-meshheading:19289085... | lld:pubmed |
| pubmed-article:19289085 | pubmed:meshHeading | pubmed-meshheading:19289085... | lld:pubmed |
| pubmed-article:19289085 | pubmed:meshHeading | pubmed-meshheading:19289085... | lld:pubmed |
| pubmed-article:19289085 | pubmed:meshHeading | pubmed-meshheading:19289085... | lld:pubmed |
| pubmed-article:19289085 | pubmed:meshHeading | pubmed-meshheading:19289085... | lld:pubmed |
| pubmed-article:19289085 | pubmed:meshHeading | pubmed-meshheading:19289085... | lld:pubmed |
| pubmed-article:19289085 | pubmed:meshHeading | pubmed-meshheading:19289085... | lld:pubmed |
| pubmed-article:19289085 | pubmed:meshHeading | pubmed-meshheading:19289085... | lld:pubmed |
| pubmed-article:19289085 | pubmed:meshHeading | pubmed-meshheading:19289085... | lld:pubmed |
| pubmed-article:19289085 | pubmed:meshHeading | pubmed-meshheading:19289085... | lld:pubmed |
| pubmed-article:19289085 | pubmed:meshHeading | pubmed-meshheading:19289085... | lld:pubmed |
| pubmed-article:19289085 | pubmed:meshHeading | pubmed-meshheading:19289085... | lld:pubmed |
| pubmed-article:19289085 | pubmed:meshHeading | pubmed-meshheading:19289085... | lld:pubmed |
| pubmed-article:19289085 | pubmed:meshHeading | pubmed-meshheading:19289085... | lld:pubmed |
| pubmed-article:19289085 | pubmed:meshHeading | pubmed-meshheading:19289085... | lld:pubmed |
| pubmed-article:19289085 | pubmed:meshHeading | pubmed-meshheading:19289085... | lld:pubmed |
| pubmed-article:19289085 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19289085 | pubmed:articleTitle | The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. | lld:pubmed |
| pubmed-article:19289085 | pubmed:affiliation | Laboratory for Embryonic Induction, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan. | lld:pubmed |
| pubmed-article:19289085 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19289085 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:12591 | entrezgene:pubmed | pubmed-article:19289085 | lld:entrezgene |
| entrez-gene:16798 | entrezgene:pubmed | pubmed-article:19289085 | lld:entrezgene |
| entrez-gene:21679 | entrezgene:pubmed | pubmed-article:19289085 | lld:entrezgene |
| entrez-gene:22601 | entrezgene:pubmed | pubmed-article:19289085 | lld:entrezgene |
| entrez-gene:50523 | entrezgene:pubmed | pubmed-article:19289085 | lld:entrezgene |
| entrez-gene:97064 | entrezgene:pubmed | pubmed-article:19289085 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19289085 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19289085 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19289085 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19289085 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19289085 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19289085 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19289085 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19289085 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19289085 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19289085 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19289085 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19289085 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19289085 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19289085 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19289085 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19289085 | lld:pubmed |
