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rdf:type |
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lifeskim:mentions |
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0441655,
umls-concept:C0449432,
umls-concept:C0449774,
umls-concept:C1179435,
umls-concept:C1283994,
umls-concept:C1420682,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1705248,
umls-concept:C2752244
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pubmed:issue |
3
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pubmed:dateCreated |
2009-3-17
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pubmed:abstractText |
Outside cells of the preimplantation mouse embryo form the trophectoderm (TE), a process requiring the transcription factor Tead4. Here, we show that transcriptionally active Tead4 can induce Cdx2 and other trophoblast genes in parallel in embryonic stem cells. In embryos, the Tead4 coactivator protein Yap localizes to nuclei of outside cells, and modulation of Tead4 or Yap activity leads to changes in Cdx2 expression. In inside cells, Yap is phosphorylated and cytoplasmic, and this involves the Hippo signaling pathway component Lats. We propose that active Tead4 promotes TE development in outside cells, whereas Tead4 activity is suppressed in inside cells by cell contact- and Lats-mediated inhibition of nuclear Yap localization. Thus, differential signaling between inside and outside cell populations leads to changes in cell fate specification during TE formation.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Cdx2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lats1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Muscle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Tead4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Yap protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1878-1551
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pubmed:author |
pubmed-author:AdachiKenjiroK,
pubmed-author:HiraharaShinoS,
pubmed-author:InoueKen-ichiK,
pubmed-author:KiyonariHiroshiH,
pubmed-author:KuriharaHirokiH,
pubmed-author:MakitaRyosukeR,
pubmed-author:Morin-KensickiElizabeth MEM,
pubmed-author:NakaoKazukiK,
pubmed-author:NishiokaNoriyukiN,
pubmed-author:NiwaHitoshiH,
pubmed-author:NojimaHiroshiH,
pubmed-author:OgonukiNarumiN,
pubmed-author:OtaMitsunoriM,
pubmed-author:RalstonAmyA,
pubmed-author:RossantJanetJ,
pubmed-author:SasakiHiroshiH,
pubmed-author:StephensonRobert ORO,
pubmed-author:YabutaNorikazuN
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pubmed:issnType |
Electronic
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
398-410
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pubmed:dateRevised |
2011-4-22
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pubmed:meshHeading |
pubmed-meshheading:19289085-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:19289085-Animals,
pubmed-meshheading:19289085-Blastocyst Inner Cell Mass,
pubmed-meshheading:19289085-Cells, Cultured,
pubmed-meshheading:19289085-DNA-Binding Proteins,
pubmed-meshheading:19289085-Ectoderm,
pubmed-meshheading:19289085-Embryo Culture Techniques,
pubmed-meshheading:19289085-Embryonic Stem Cells,
pubmed-meshheading:19289085-Female,
pubmed-meshheading:19289085-Gene Expression Regulation, Developmental,
pubmed-meshheading:19289085-Homeodomain Proteins,
pubmed-meshheading:19289085-Mice,
pubmed-meshheading:19289085-Mice, Inbred C57BL,
pubmed-meshheading:19289085-Mice, Inbred DBA,
pubmed-meshheading:19289085-Mice, Mutant Strains,
pubmed-meshheading:19289085-Mice, Transgenic,
pubmed-meshheading:19289085-Models, Biological,
pubmed-meshheading:19289085-Muscle Proteins,
pubmed-meshheading:19289085-Phosphoproteins,
pubmed-meshheading:19289085-Pregnancy,
pubmed-meshheading:19289085-Protein-Serine-Threonine Kinases,
pubmed-meshheading:19289085-Signal Transduction,
pubmed-meshheading:19289085-Transcription Factors,
pubmed-meshheading:19289085-Trophoblasts
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pubmed:year |
2009
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pubmed:articleTitle |
The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass.
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pubmed:affiliation |
Laboratory for Embryonic Induction, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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