Source:http://linkedlifedata.com/resource/pubmed/id/19288455
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2009-3-19
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pubmed:abstractText |
The aim of this study was to investigate lipid profile, paraoxonase 1 (PON1) activity, and oxidative stress status in the serum of hyperemesis gravidarum (HG) patients. Thirty-six HG cases and 36 normal pregnants were included in the study. Serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apoproteins A1 (apo A1) and B (apo B), malondialdehyde (MDA), and total antioxidant activity (TAO) values and PON1 and arylesterase activities were determined. Although serum TC, TG, LDL-C, and apo B levels were not different among; the groups (P>0.05), HDL-C (P=0.01) and apo A1 (P=0.007) levels were lower in HG patients than in normal pregnants. HG group had significantly lower serum PON1 (P=0.03) and arylesterase activities (P=0.03) compared with the control group. Additionally, mean TAO values were lower (P=0.01) and MDA levels were higher (P=0.02) in HG group than in the healthy pregnants. A significant negative correlation between PON1 and MDA was found in HG group (r=-0.33, P<0.05). The findings of this study have revealed that HG may be one of the conditions in which oxidant and antioxidant balance is impaired.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aryldialkylphosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Malondialdehyde,
http://linkedlifedata.com/resource/pubmed/chemical/PON1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides
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pubmed:status |
MEDLINE
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pubmed:issn |
1098-2825
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pubmed:author | |
pubmed:copyrightInfo |
(c) 2009 Wiley-Liss, Inc.
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pubmed:issnType |
Electronic
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
105-9
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pubmed:meshHeading |
pubmed-meshheading:19288455-Adult,
pubmed-meshheading:19288455-Aryldialkylphosphatase,
pubmed-meshheading:19288455-Cholesterol,
pubmed-meshheading:19288455-Female,
pubmed-meshheading:19288455-Humans,
pubmed-meshheading:19288455-Hyperemesis Gravidarum,
pubmed-meshheading:19288455-Lipids,
pubmed-meshheading:19288455-Lipoproteins,
pubmed-meshheading:19288455-Malondialdehyde,
pubmed-meshheading:19288455-Oxidative Stress,
pubmed-meshheading:19288455-Pregnancy,
pubmed-meshheading:19288455-Statistics, Nonparametric,
pubmed-meshheading:19288455-Triglycerides
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pubmed:year |
2009
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pubmed:articleTitle |
Serum lipid profile, oxidative status, and paraoxonase 1 activity in hyperemesis gravidarum.
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pubmed:affiliation |
Department of Biochemistry, School of Medicine, Ataturk University, Erzurum, Turkey. aksoyhulya@yahoo.com
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pubmed:publicationType |
Journal Article
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