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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-6-8
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pubmed:abstractText |
Deficiency of dihydropyrimidine dehydrogenase (DPD) has been associated with severe fluoropyrimidines (FP) toxicity. Mutations in DPD-coding gene (DPYD) were shown to increase the risk of severe toxicity in FP-treated cancer patients. However, the majority of DPYD alterations characterized in these patients has been considered as polymorphisms and known deleterious mutations are rare and present in only limited subgroup of patients with high toxicity. Recently, the common fragile site FRA1E was mapped within DPYD locus but intragenic rearrangements in DPYD gene were not studied so far.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1432-0843
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
615-8
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pubmed:meshHeading |
pubmed-meshheading:19288105-Adult,
pubmed-meshheading:19288105-Aged,
pubmed-meshheading:19288105-Antimetabolites, Antineoplastic,
pubmed-meshheading:19288105-Dihydrouracil Dehydrogenase (NADP),
pubmed-meshheading:19288105-Exons,
pubmed-meshheading:19288105-Female,
pubmed-meshheading:19288105-Fluorouracil,
pubmed-meshheading:19288105-Gastrointestinal Diseases,
pubmed-meshheading:19288105-Hematologic Diseases,
pubmed-meshheading:19288105-Humans,
pubmed-meshheading:19288105-Male,
pubmed-meshheading:19288105-Middle Aged,
pubmed-meshheading:19288105-Mutation,
pubmed-meshheading:19288105-Neoplasms,
pubmed-meshheading:19288105-Nucleic Acid Amplification Techniques,
pubmed-meshheading:19288105-Polymorphism, Genetic,
pubmed-meshheading:19288105-Pyrimidines,
pubmed-meshheading:19288105-Severity of Illness Index
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pubmed:year |
2009
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pubmed:articleTitle |
Lack of large intragenic rearrangements in dihydropyrimidine dehydrogenase (DPYD) gene in fluoropyrimidine-treated patients with high-grade toxicity.
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pubmed:affiliation |
Institute of Biochemistry and Experimental Oncology, 1st Faculty of Medicine, Charles University in Prague, Prague 2, Czech Republic.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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