| pubmed-article:19286971 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19286971 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:19286971 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:19286971 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:19286971 | lifeskim:mentions | umls-concept:C0039044 | lld:lifeskim |
| pubmed-article:19286971 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:19286971 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:19286971 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:19286971 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:19286971 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:19286971 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:19286971 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:19286971 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:19286971 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:19286971 | pubmed:dateCreated | 2009-4-1 | lld:pubmed |
| pubmed-article:19286971 | pubmed:abstractText | Despite the longstanding appreciation of communication between the nervous and the immune systems, the nature and significance of these interactions to immunity remain enigmatic. Here, we show that 6-hydroxydopamine-mediated ablation of the mouse peripheral sympathetic nervous system increases primary CD8(+) T cell responses to viral and cellular antigens presented by direct priming or cross-priming. The sympathetic nervous system also suppresses antiviral CD4(+) T cell responses, but this is not required for suppressing CD8(+) T cell responses. Adoptive transfer experiments indicate that enhanced CD8(+) responses do not result from permanent alterations in CD8(+) T cell function in sympathectomized mice. Rather, additional findings suggest that the sympathetic nervous system tempers the capacity of antigen-presenting cells to activate naïve CD8(+) T cells. We also show that antiviral CD8(+) T cell responses are enhanced by administration of a beta(2) (but not beta(1) or alpha) adrenergic antagonist. These findings demonstrate a critical role for the sympathetic nervous system in limiting CD8(+) T cell responses and indicate that CD8(+) T cell responses may be altered in patients using beta-blockers, one of the most widely prescribed classes of drugs. | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19286971 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19286971 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19286971 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19286971 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:19286971 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:19286971 | pubmed:author | pubmed-author:BenninkJack... | lld:pubmed |
| pubmed-article:19286971 | pubmed:author | pubmed-author:YewdellJonath... | lld:pubmed |
| pubmed-article:19286971 | pubmed:author | pubmed-author:HickmanHeathe... | lld:pubmed |
| pubmed-article:19286971 | pubmed:author | pubmed-author:TakedaKazuyoK | lld:pubmed |
| pubmed-article:19286971 | pubmed:author | pubmed-author:GrebeKristie... | lld:pubmed |
| pubmed-article:19286971 | pubmed:author | pubmed-author:IrvineKari... | lld:pubmed |
| pubmed-article:19286971 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19286971 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:19286971 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:19286971 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19286971 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19286971 | pubmed:pagination | 5300-5 | lld:pubmed |
| pubmed-article:19286971 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:19286971 | pubmed:meshHeading | pubmed-meshheading:19286971... | lld:pubmed |
| pubmed-article:19286971 | pubmed:meshHeading | pubmed-meshheading:19286971... | lld:pubmed |
| pubmed-article:19286971 | pubmed:meshHeading | pubmed-meshheading:19286971... | lld:pubmed |
| pubmed-article:19286971 | pubmed:meshHeading | pubmed-meshheading:19286971... | lld:pubmed |
| pubmed-article:19286971 | pubmed:meshHeading | pubmed-meshheading:19286971... | lld:pubmed |
| pubmed-article:19286971 | pubmed:meshHeading | pubmed-meshheading:19286971... | lld:pubmed |
| pubmed-article:19286971 | pubmed:meshHeading | pubmed-meshheading:19286971... | lld:pubmed |
| pubmed-article:19286971 | pubmed:meshHeading | pubmed-meshheading:19286971... | lld:pubmed |
| pubmed-article:19286971 | pubmed:meshHeading | pubmed-meshheading:19286971... | lld:pubmed |
| pubmed-article:19286971 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19286971 | pubmed:articleTitle | Sympathetic nervous system control of anti-influenza CD8+ T cell responses. | lld:pubmed |
| pubmed-article:19286971 | pubmed:affiliation | Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. | lld:pubmed |
| pubmed-article:19286971 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19286971 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19286971 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19286971 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19286971 | lld:pubmed |
