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rdf:type |
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lifeskim:mentions |
umls-concept:C0039044,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0871261,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1704632,
umls-concept:C1706438,
umls-concept:C1706817,
umls-concept:C2587213,
umls-concept:C2698600,
umls-concept:C2911692
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pubmed:issue |
13
|
|
pubmed:dateCreated |
2009-4-1
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|
pubmed:abstractText |
Despite the longstanding appreciation of communication between the nervous and the immune systems, the nature and significance of these interactions to immunity remain enigmatic. Here, we show that 6-hydroxydopamine-mediated ablation of the mouse peripheral sympathetic nervous system increases primary CD8(+) T cell responses to viral and cellular antigens presented by direct priming or cross-priming. The sympathetic nervous system also suppresses antiviral CD4(+) T cell responses, but this is not required for suppressing CD8(+) T cell responses. Adoptive transfer experiments indicate that enhanced CD8(+) responses do not result from permanent alterations in CD8(+) T cell function in sympathectomized mice. Rather, additional findings suggest that the sympathetic nervous system tempers the capacity of antigen-presenting cells to activate naïve CD8(+) T cells. We also show that antiviral CD8(+) T cell responses are enhanced by administration of a beta(2) (but not beta(1) or alpha) adrenergic antagonist. These findings demonstrate a critical role for the sympathetic nervous system in limiting CD8(+) T cell responses and indicate that CD8(+) T cell responses may be altered in patients using beta-blockers, one of the most widely prescribed classes of drugs.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-10024333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-10888631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-11390439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-11390496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-11739518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-11846439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-12161026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-12480496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-12480505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-12626550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-13463800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-14597102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-15331123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-16557263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-16611891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-16855146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-16920927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-18495255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-2188579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-2756050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-2767160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-2839301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-3177665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-3902888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-4376244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-451988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-4973518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-6168212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-6813289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-7929806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-9126981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-9445050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-9629306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19286971-9698255
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1091-6490
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:day |
31
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5300-5
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
|
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pubmed:year |
2009
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pubmed:articleTitle |
Sympathetic nervous system control of anti-influenza CD8+ T cell responses.
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pubmed:affiliation |
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
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