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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-4-7
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pubmed:abstractText |
Cholesterol 24S-hydroxylase (CYP46) catalyzes the conversion of cholesterol to 24S-hydroxycholesterol, the primary cerebral cholesterol elimination product. Only few gene variations in CYP46 gene (CYP46A1) have been investigated for their relevance as genetic risk factors of Alzheimer's disease (AD) and results are contradictory.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0924-9338
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
183-90
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19286353-Aged,
pubmed-meshheading:19286353-Aged, 80 and over,
pubmed-meshheading:19286353-Alzheimer Disease,
pubmed-meshheading:19286353-Amyloid beta-Peptides,
pubmed-meshheading:19286353-Brain,
pubmed-meshheading:19286353-Cholesterol,
pubmed-meshheading:19286353-Female,
pubmed-meshheading:19286353-Genetic Predisposition to Disease,
pubmed-meshheading:19286353-Genetic Variation,
pubmed-meshheading:19286353-Haplotypes,
pubmed-meshheading:19286353-Humans,
pubmed-meshheading:19286353-Hydroxycholesterols,
pubmed-meshheading:19286353-Male,
pubmed-meshheading:19286353-Middle Aged,
pubmed-meshheading:19286353-Polymorphism, Single Nucleotide,
pubmed-meshheading:19286353-Risk Factors,
pubmed-meshheading:19286353-Steroid Hydroxylases
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pubmed:year |
2009
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pubmed:articleTitle |
CYP46A1 variants influence Alzheimer's disease risk and brain cholesterol metabolism.
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pubmed:affiliation |
Department of Psychiatry, University of Bonn, Germany. heike.koelsch@ukb.uni-bonn.de
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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