Source:http://linkedlifedata.com/resource/pubmed/id/19285633
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2009-3-16
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| pubmed:abstractText |
Between August 1996 and December 2004, 369 patients with a median age of 41 years (range: 1-68 years) received stem cell transplantation (SCT) from unrelated donors after an antithymocyte-globulin (ATG)-containing conditioning regimen. In 268 patients, complete molecular typing (4-digit) of HLA-A, -B, -C, -DRB1, and -DQB1 was available: 110 patients were completely matched for 10 alleles, 91 patients had 1 allele-mismatch (9/10), and 67 patients were mismatched for 2-4 alleles (6-8/10). The incidence of grade II-IV acute graft-versus-host disease (aGVHD) was 33% in the 10/10, 41% in the 9/10, and 40% in the 6-8/10 group, respectively (P = .1). The cumulative incidence of treatment-related mortality (TRM) and relapse among the groups were similar (27%, 31%, and 32%, P = .2; and 28%, 27%, and 26%, P = .9. After a median follow-up of 35 months (range: 3-120 months), the estimated 5-year disease-free survival (DFS) was 42% and did not differ among the 10/10, the 9/10, and the 6-8/10-mismatched groups (45% versus 42% versus 39%) (P = .5). In multivariate analysis, only age (hazard ratio [HR] 1.013) (P = .004) and bad-risk disease (HR 1.975) (P < .001) were independent risk factors for DFS. In conclusion, pretransplant ATG allows allogeneic SCT from unrelated donors with HLA disparities.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
1523-6536
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| pubmed:author |
pubmed-author:AmtsfeldGittaG,
pubmed-author:AyukFrancisF,
pubmed-author:BacherUlrikeU,
pubmed-author:BinderThomasT,
pubmed-author:EiermannThomasT,
pubmed-author:ErttmannRolfR,
pubmed-author:KrögerNicolausN,
pubmed-author:LellekHeinrichH,
pubmed-author:SchrumJohannaJ,
pubmed-author:ZabelinaTatjanaT,
pubmed-author:ZanderAxelA
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| pubmed:issnType |
Electronic
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| pubmed:volume |
15
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
454-62
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| pubmed:meshHeading |
pubmed-meshheading:19285633-Acute Disease,
pubmed-meshheading:19285633-Adolescent,
pubmed-meshheading:19285633-Adult,
pubmed-meshheading:19285633-Age Factors,
pubmed-meshheading:19285633-Aged,
pubmed-meshheading:19285633-Antilymphocyte Serum,
pubmed-meshheading:19285633-Child,
pubmed-meshheading:19285633-Child, Preschool,
pubmed-meshheading:19285633-Female,
pubmed-meshheading:19285633-Graft vs Host Disease,
pubmed-meshheading:19285633-HLA Antigens,
pubmed-meshheading:19285633-Hematologic Neoplasms,
pubmed-meshheading:19285633-Histocompatibility Testing,
pubmed-meshheading:19285633-Humans,
pubmed-meshheading:19285633-Immunosuppressive Agents,
pubmed-meshheading:19285633-Incidence,
pubmed-meshheading:19285633-Infant,
pubmed-meshheading:19285633-Living Donors,
pubmed-meshheading:19285633-Male,
pubmed-meshheading:19285633-Middle Aged,
pubmed-meshheading:19285633-Recurrence,
pubmed-meshheading:19285633-Retrospective Studies,
pubmed-meshheading:19285633-Risk Factors,
pubmed-meshheading:19285633-Stem Cell Transplantation,
pubmed-meshheading:19285633-Survival Rate,
pubmed-meshheading:19285633-Transplantation Conditioning
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| pubmed:year |
2009
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| pubmed:articleTitle |
HLA-mismatched unrelated donors as an alternative graft source for allogeneic stem cell transplantation after antithymocyte globulin-containing conditioning regimen.
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| pubmed:affiliation |
Department of Stem Cell Transplantation, University Hospital Hamburg-Eppendorf, Hamburg, Germany. nkroeger@uke.uni-hamburg.de
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| pubmed:publicationType |
Journal Article
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