Source:http://linkedlifedata.com/resource/pubmed/id/19285041
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2009-4-13
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| pubmed:abstractText |
Tyrosine hydroxylase is the rate-limiting enzyme in the synthesis of dopamine, a key neurotransmitter in the regulation of food intake. This study examined tyrosine hydroxylase mRNA expression in obese mice fed a high-fat diet. After 8 week feeding of high-fat diet mice were classified as diet-induced obese and obese-resistant according to body weight gain. They were then placed on different dietary interventions including a high-fat diet, a low-fat diet and an energy-restricted high-fat diet for six weeks. The control group was fed a low-fat diet. The results revealed that tyrosine hydroxylase mRNA expression was significantly decreased in the ventral tegmental area (VTA), ventromedial hypothalamic nucleus (VMH), and substantia nigra (SN) of the high-fat diet-induced obese (-29%, -26% and -26%) and obese-resistant mice (-21%, -24% and -18%) compared to controls. After switching the diet from high to low-fat diet tyrosine hydroxylase mRNA was increased in the VTA, VMH, and SN of the diet-induced obese mice and in the VMH, and SN of the obese-resistant mice. Energy restriction, even with high-fat feeding, reduced tyrosine hydroxylase mRNA expression in the VTA, VMH, and SN compared to controls. In addition, tyrosine hydroxylase mRNA expression in the VTA, VMH, and SN showed a significant negative correlation with plasma leptin levels. This study suggests that the up- or down-regulation of tyrosine hydroxylase mRNA expression in the VTA, VMH, and SN is mainly due to the intake of macronutrient type rather than body weight.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine 3-Monooxygenase
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1872-6240
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
1
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| pubmed:volume |
1268
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
181-9
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:19285041-Adipocytes, White,
pubmed-meshheading:19285041-Animals,
pubmed-meshheading:19285041-Body Composition,
pubmed-meshheading:19285041-Body Weight,
pubmed-meshheading:19285041-Brain,
pubmed-meshheading:19285041-Diet,
pubmed-meshheading:19285041-Dietary Fats,
pubmed-meshheading:19285041-Down-Regulation,
pubmed-meshheading:19285041-Energy Intake,
pubmed-meshheading:19285041-Genetic Predisposition to Disease,
pubmed-meshheading:19285041-Insulin,
pubmed-meshheading:19285041-Leptin,
pubmed-meshheading:19285041-Male,
pubmed-meshheading:19285041-Mice,
pubmed-meshheading:19285041-Mice, Inbred C57BL,
pubmed-meshheading:19285041-Obesity,
pubmed-meshheading:19285041-RNA, Messenger,
pubmed-meshheading:19285041-Substantia Nigra,
pubmed-meshheading:19285041-Tyrosine 3-Monooxygenase,
pubmed-meshheading:19285041-Ventral Tegmental Area,
pubmed-meshheading:19285041-Ventromedial Hypothalamic Nucleus
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| pubmed:year |
2009
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| pubmed:articleTitle |
High-fat diet decreases tyrosine hydroxylase mRNA expression irrespective of obesity susceptibility in mice.
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| pubmed:affiliation |
Institute of Biochemistry and Molecular Biology, Lanzhou University, PR China.
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| pubmed:publicationType |
Journal Article
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