rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-3-25
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pubmed:abstractText |
During malaria infection the Toll-like receptor 9 (TLR9) is activated through induction with plasmodium DNA or another malaria motif not yet identified. Although TLR9 activation by malaria parasites is well reported, the implication to the susceptibility to severe malaria is not clear. The aim of this study was to assess the contribution of genetic variation at TLR9 to severe malaria.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1475-2875
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pubmed:author |
pubmed-author:AuburnSarahS,
pubmed-author:CampinoSusanaS,
pubmed-author:ClarkTaane GTG,
pubmed-author:DiakiteMahamadouM,
pubmed-author:FortonJulianJ,
pubmed-author:FryAndrewA,
pubmed-author:HullJeremyJ,
pubmed-author:JallowMuminatouM,
pubmed-author:KwiatkowskiDominic PDP,
pubmed-author:MolyneuxMalcolm EME,
pubmed-author:PinderMargaretM,
pubmed-author:RichardsonAnnaA,
pubmed-author:RockettKirkK,
pubmed-author:Sisay-JoofFatouF,
pubmed-author:TaylorTerrie ETE
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
44
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:19284650-Animals,
pubmed-meshheading:19284650-Case-Control Studies,
pubmed-meshheading:19284650-Chromosome Mapping,
pubmed-meshheading:19284650-Gambia,
pubmed-meshheading:19284650-Gene Expression,
pubmed-meshheading:19284650-Genetic Predisposition to Disease,
pubmed-meshheading:19284650-Genotype,
pubmed-meshheading:19284650-Haplotypes,
pubmed-meshheading:19284650-Humans,
pubmed-meshheading:19284650-Logistic Models,
pubmed-meshheading:19284650-Malaria, Falciparum,
pubmed-meshheading:19284650-Malawi,
pubmed-meshheading:19284650-Phenotype,
pubmed-meshheading:19284650-Plasmodium falciparum,
pubmed-meshheading:19284650-Polymorphism, Single Nucleotide,
pubmed-meshheading:19284650-Toll-Like Receptor 9
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pubmed:year |
2009
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pubmed:articleTitle |
TLR9 polymorphisms in African populations: no association with severe malaria, but evidence of cis-variants acting on gene expression.
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pubmed:affiliation |
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. sc11@sanger.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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