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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-4-9
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pubmed:abstractText |
Timolol is used topically for the treatment of glaucoma and metabolized by cytochrome P450 (CYP) 2D6 in the liver. The aim of this study is to test the hypothesis that CYP 2D6 single-nucleotide polymorphism (SNP) is associated with drug effects of ophthalmic timolol.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1557-7732
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
163-71
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pubmed:meshHeading |
pubmed-meshheading:19284319-Administration, Topical,
pubmed-meshheading:19284319-Adolescent,
pubmed-meshheading:19284319-Adrenergic beta-Antagonists,
pubmed-meshheading:19284319-Adult,
pubmed-meshheading:19284319-Aged,
pubmed-meshheading:19284319-Aged, 80 and over,
pubmed-meshheading:19284319-Bradycardia,
pubmed-meshheading:19284319-Cytochrome P-450 CYP2D6,
pubmed-meshheading:19284319-Female,
pubmed-meshheading:19284319-Genotype,
pubmed-meshheading:19284319-Glaucoma, Open-Angle,
pubmed-meshheading:19284319-Heart Rate,
pubmed-meshheading:19284319-Humans,
pubmed-meshheading:19284319-Intraocular Pressure,
pubmed-meshheading:19284319-Male,
pubmed-meshheading:19284319-Middle Aged,
pubmed-meshheading:19284319-Ophthalmic Solutions,
pubmed-meshheading:19284319-Polymorphism, Single Nucleotide,
pubmed-meshheading:19284319-Timolol,
pubmed-meshheading:19284319-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Cytochrome oxidase 2D6 gene polymorphism in primary open-angle glaucoma with various effects to ophthalmic timolol.
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pubmed:affiliation |
Zhongshan Ophthalmic Center, Sun Yat-sen University, State Key Laboratory of Ophthalmology, Guangzhou, People's Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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