Source:http://linkedlifedata.com/resource/pubmed/id/19283778
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2009-4-13
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| pubmed:abstractText |
IFN regulatory factor 7 (IRF7) has been described as the master regulator of type I IFN responses and has been shown to be critical for innate antiviral immunity in vivo. In addition to type I IFN, NK cell responses are involved in the control of viral replication during acute viral infection. To investigate the role of IRF7 in the context of a viral infection that induces a strong NK cell response, the murine cytomegalovirus (MCMV) infection model was used. WT, IRF7-deficient and IRF3/IRF7-double deficient mice were infected with MCMV. The systemic IFN-alpha response to MCMV was entirely dependent on IRF7, but independent of IRF3. However, peak IFN-beta production during MCMV infection was not affected by the lack of IRF7 or both IRF7 and IRF3. Despite the complete lack of IFN-alpha production IRF7- and IRF3/IRF7-deficient mice were surprisingly efficient in controlling MCMV replication and were only modestly more susceptible to MCMV infection than WT mice. NK cell cytotoxicity was unimpaired and NK cell IFN-gamma production was enhanced in IRF7-deficient mice correlating with increased levels of bioactive IL-12. Owing to these compensatory mechanisms IRF7-dependent antiviral immune responses were not essential for resistance against acute MCMV infection in vivo.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Regulatory Factor-3,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Regulatory Factor-7,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Irf3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Irf7 protein, mouse
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| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
1521-4141
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
39
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1007-18
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| pubmed:meshHeading |
pubmed-meshheading:19283778-Animals,
pubmed-meshheading:19283778-Cell Line,
pubmed-meshheading:19283778-Cytotoxicity, Immunologic,
pubmed-meshheading:19283778-Dendritic Cells,
pubmed-meshheading:19283778-Herpesviridae Infections,
pubmed-meshheading:19283778-Interferon Regulatory Factor-3,
pubmed-meshheading:19283778-Interferon Regulatory Factor-7,
pubmed-meshheading:19283778-Interferon-alpha,
pubmed-meshheading:19283778-Interferon-beta,
pubmed-meshheading:19283778-Interferon-gamma,
pubmed-meshheading:19283778-Interleukin-12,
pubmed-meshheading:19283778-Killer Cells, Natural,
pubmed-meshheading:19283778-Lymphocyte Activation,
pubmed-meshheading:19283778-Mice,
pubmed-meshheading:19283778-Mice, Inbred BALB C,
pubmed-meshheading:19283778-Mice, Inbred C57BL,
pubmed-meshheading:19283778-Mice, Knockout,
pubmed-meshheading:19283778-Muromegalovirus,
pubmed-meshheading:19283778-Virus Replication
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| pubmed:year |
2009
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| pubmed:articleTitle |
The IFN regulatory factor 7-dependent type I IFN response is not essential for early resistance against murine cytomegalovirus infection.
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| pubmed:affiliation |
II. Medizinische Klinik, Klinikum Rechts der Isar, Technical University Munich, Munich, Germany.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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