Linked Life Data

19282342

Source:http://linkedlifedata.com/resource/pubmed/id/19282342

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-10-2
pubmed:abstractText
We studied the distribution profiles and repeatability of key exercise performance parameters in the first large multicentre trials to include these measurements in chronic obstructive pulmonary disease (COPD). After a screening visit, 463 subjects with COPD (mean+/-SD forced expiratory volume in 1 s 43+/-13% predicted) completed two run-in visits before treatment randomisation. At the run-in visits, measurements were conducted at rest, at a standardised time near end-exercise (isotime) and at peak exercise during constant work rate (CWR) cycle tests at 75% of each individual's maximum work capacity. The intraclass correlation coefficient was used to evaluate the test-retest repeatability of measurements of endurance time (ET), inspiratory capacity (IC), ventilation and dyspnoea intensity (Borg scale) during exercise. IC, ventilation and dyspnoea ratings were normally distributed; ET showed rightward skew (median<mean, skewness of 10.9 (much greater than zero)) with 16% of the sample exceeding 1 SD of the mean. ET was highly repeatable across run-in visits: 7.9+/-4.8 and 8.4+/-5.1 min (R = 0.84). IC values at rest, isotime and peak exercise were all highly repeatable (R > or = 0.87). Ventilation was repeatable over the same time-points (R > or = 0.92), as was dyspnoea intensity at isotime (R = 0.79) and at peak exercise (R = 0.81). In conclusion, key perceptual and ventilatory parameters can be reliably measured during CWR cycle exercise in multicentre clinical trials in moderate to very severe COPD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1399-3003
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
866-74
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Reliability of ventilatory parameters during cycle ergometry in multicentre trials in COPD.
pubmed:affiliation
Dept of Medicine, Queen's University and Kingston General Hospital, Kingston, ON, Canada. odonnell@queensu.ca
pubmed:publicationType
Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Multicenter Study, Validation Studies