Source:http://linkedlifedata.com/resource/pubmed/id/19282172
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2009-4-3
|
| pubmed:abstractText |
The designed and synthesized 2-(4-methoxyphenyl) ethyl] acetamide derivatives (3a, 3b and 3c) were evaluated for their PTP1B inhibitory activity where they showed IC(50) values 69 microM, 87 microM and 71 microM, respectively. These results correlated well with the docking studies and in vivo screening of the compounds for their antidiabetic activity in SLM and STZ models.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1464-3405
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2320-3
|
| pubmed:meshHeading |
pubmed-meshheading:19282172-Animals,
pubmed-meshheading:19282172-Binding Sites,
pubmed-meshheading:19282172-Crystallography, X-Ray,
pubmed-meshheading:19282172-Diabetes Mellitus, Experimental,
pubmed-meshheading:19282172-Drug Delivery Systems,
pubmed-meshheading:19282172-Hypoglycemic Agents,
pubmed-meshheading:19282172-Models, Molecular,
pubmed-meshheading:19282172-Protein Tyrosine Phosphatase, Non-Receptor Type 1,
pubmed-meshheading:19282172-Rats
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Synthesis of protein tyrosine phosphatase 1B inhibitors: model validation and docking studies.
|
| pubmed:affiliation |
Central Drug Research Institute, Medicinal and Process Chemistry, Chattar Manzil Palace, Mahatma Gandhi Marg, Lucknow, Uttar Pradesh, India. anilsak@gmail.com
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Validation Studies
|