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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
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|
pubmed:dateCreated |
2009-4-10
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|
pubmed:abstractText |
The first synthesis of the ganglioside LLG-3 tetrasaccharide, which has attractive biological activities as well as a unique structure, is described. A C8-methoxy decorated sialic acid building block was initially prepared and a glycolic acid moiety was then introduced by sialylation. Amide condensation between the sialyl glycolic acid and an amino group at C5 on the sialyllactoside unit afforded the fully protected LLG-3 tetrasaccharide. Finally, the desired tetrasaccharide part of LLG-3 was obtained after careful global deprotection. [structure: see text].
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Apr
|
|
pubmed:issn |
1873-426X
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|
pubmed:author |
|
|
pubmed:issnType |
Electronic
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|
pubmed:day |
21
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|
pubmed:volume |
344
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|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
747-52
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|
pubmed:meshHeading |
|
|
pubmed:year |
2009
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|
pubmed:articleTitle |
Synthesis of the starfish ganglioside LLG-3 tetrasaccharide.
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|
pubmed:affiliation |
Material and Life Chemistry, Faculty of Engineering, Kanagawa University, Yokohama, Kanagawa, Japan.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
