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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2009-4-27
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pubmed:abstractText |
Chronic hepatitis induced liver fibrogenesis is characterized by epithelial-to-mesenchymal transition of liver parenchymal cells (hepatocytes) to fibroblast (-like cells), i.e. increasing hepatocellular dedifferentiation, ultimatively leading to the development of hepatocellular carcinoma (HCC). Up to now the spectrum of valid serum biomarkers for this process of hepatocellular dedifferentiation is very limited. We therefore investigated the dynamics of alterations in the serum transferrin isoform pattern in the pathogenetic sequence from liver fibrosis to hepatocellular carcinoma, to evaluate the suitability of one of the isoforms as potential biomarker for hepatocellular dedifferentiation in chronic liver disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1873-3492
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
403
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
188-93
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19281805-Adult,
pubmed-meshheading:19281805-Aged,
pubmed-meshheading:19281805-Biological Markers,
pubmed-meshheading:19281805-Carcinoma, Hepatocellular,
pubmed-meshheading:19281805-Case-Control Studies,
pubmed-meshheading:19281805-Cell Dedifferentiation,
pubmed-meshheading:19281805-Chronic Disease,
pubmed-meshheading:19281805-Continental Population Groups,
pubmed-meshheading:19281805-Female,
pubmed-meshheading:19281805-Hepatocytes,
pubmed-meshheading:19281805-Humans,
pubmed-meshheading:19281805-Liver Cirrhosis,
pubmed-meshheading:19281805-Liver Diseases,
pubmed-meshheading:19281805-Male,
pubmed-meshheading:19281805-Middle Aged,
pubmed-meshheading:19281805-Protein Isoforms,
pubmed-meshheading:19281805-Sialoglycoproteins,
pubmed-meshheading:19281805-Transferrin
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pubmed:year |
2009
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pubmed:articleTitle |
Evaluation of serum percent trisialotransferrin as potential predictive biomarker of hepatocellular dedifferentiation in chronic liver disease.
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pubmed:affiliation |
Institute of Clinical Chemistry and Pathobiochemistry/Central Laboratory, RWTH-University Hospital, Aachen, Germany. ogressner@ukaachen.de
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pubmed:publicationType |
Journal Article
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