Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1991-11-21
pubmed:abstractText
A complex segregation analysis of autism in 185 Utah families was carried out using the mixed model. The 209 affected individuals in these families represent nearly complete ascertainment of the autistic cases born in Utah between 1965 and 1984. The sibling recurrence risk for autism was 4.5% (95% confidence limits 2.8%-6.2%). Likelihoods were maximized for major-gene models, a polygenic model, a sibling-effect model, and a mixed model consisting of major-gene and shared-sibling effects. The analysis provided no evidence for major-locus inheritance of autism. Subdivision of the sample according to the probands' IQ levels showed that sibling recurrence risk did not vary consistently with IQ level. A segregation analysis of families in which the proband had an IQ less than 50 also failed to provide evidence for a major locus. However, because of the etiologic heterogeneity of this disorder, genetic analysis of other meaningful subsets of families could prove informative.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-1990832, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-2142123, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-2216614, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-2244638, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-2256889, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-2333911, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-2624429, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-263583, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-2670881, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-2705478, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-2738009, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-2750975, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-2766196, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-2783539, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-2793785, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-288073, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-3048227, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-3280580, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-3341467, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-3402727, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-3513570, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-3674109, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-3726059, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-3985910, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-4030664, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-4038442, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-4038589, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-4813384, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-4842773, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-5149961, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-562353, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-5782759, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-6591796, http://linkedlifedata.com/resource/pubmed/commentcorrection/1928098-986474
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0002-9297
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
932-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Complex segregation analysis of autism.
pubmed:affiliation
Department of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't