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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1977-6-11
|
| pubmed:abstractText |
Cytolytic T lymphocytes (CTL) from murine sarcoma virus (MSV) or Friend leukaemia virus (FLV) inoculated mice lyse syngeneic much more efficiently than allogeneic FMRGi+ lymphoma cells. By comparing the cytolysis of various H-2 different 51Cr lymphomas by CTL from several inbred and congenic lines differing at H-2, and by competition experiments using unlabelled cells, one can demonstrate that this phenomenon is due to an H-2 barrier. H-2b/H-2d hybrid-anti-MSV-CTL immunized by H-2b, H-2d or H-2b/H-2d tumours lyse only FMRGi+ lymphomas of the same H-2, and their activity for a given target is inhibited only by H-2-identical competitive cells. H-2 antigens are therefore directly involved in the interaction between tumour cells and immune CTL which probably react with an 'H-2 modified' antigen of the tumour cells surface. The use of CTL from intra-H-2 recombinant lines shows that H-2D and probably H-2K molecules are involved, but vary according to the tumour cells. A possible role of the I region is discussed as well as the implications of these results in immunosurveillance against viral neoplasia.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0305-1811
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
4
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
35-45
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:192802-Animals,
pubmed-meshheading:192802-Antigens, Neoplasm,
pubmed-meshheading:192802-Antigens, Viral,
pubmed-meshheading:192802-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:192802-Friend murine leukemia virus,
pubmed-meshheading:192802-Histocompatibility Antigens,
pubmed-meshheading:192802-Immunity, Cellular,
pubmed-meshheading:192802-Leukemia, Experimental,
pubmed-meshheading:192802-Leukemia Virus, Murine,
pubmed-meshheading:192802-Mice,
pubmed-meshheading:192802-Mice, Inbred Strains,
pubmed-meshheading:192802-Moloney murine leukemia virus,
pubmed-meshheading:192802-Rauscher Virus,
pubmed-meshheading:192802-Sarcoma, Experimental,
pubmed-meshheading:192802-Sarcoma Viruses, Murine,
pubmed-meshheading:192802-T-Lymphocytes,
pubmed-meshheading:192802-Tumor Virus Infections
|
| pubmed:year |
1977
|
| pubmed:articleTitle |
Relationships between H-2 and viral antigens in murine oncornavirus-induced tumours.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro
|