Linked Life Data

19280190

Source:http://linkedlifedata.com/resource/pubmed/id/19280190

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-8-19
pubmed:abstractText
The histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), enhances cisplatin [cis-diammine dichloroplatinum (II)] (CDDP)-induced apoptosis in the oral squamous cell carcinoma (OSCC) cell line by complex, multifunctional mechanisms. We investigated the role of endoplasmic reticulum (ER) stress in the enhancing effect of SAHA on CDDP, compared with the ER stressor thapsigargin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/CASP4 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Caspase 12, http://linkedlifedata.com/resource/pubmed/chemical/Caspases, Initiator, http://linkedlifedata.com/resource/pubmed/chemical/Cinnamates, http://linkedlifedata.com/resource/pubmed/chemical/Cisplatin, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Eukaryotic Initiation Factor-2, http://linkedlifedata.com/resource/pubmed/chemical/Heat-Shock Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Hydroxamic Acids, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Protein Phosphatase 1, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt, http://linkedlifedata.com/resource/pubmed/chemical/Thapsigargin, http://linkedlifedata.com/resource/pubmed/chemical/Thiourea, http://linkedlifedata.com/resource/pubmed/chemical/Tunicamycin, http://linkedlifedata.com/resource/pubmed/chemical/Valproic Acid, http://linkedlifedata.com/resource/pubmed/chemical/endoplasmin, http://linkedlifedata.com/resource/pubmed/chemical/molecular chaperone GRP78, http://linkedlifedata.com/resource/pubmed/chemical/salubrinal, http://linkedlifedata.com/resource/pubmed/chemical/vorinostat
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1432-0843
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1115-22
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:19280190-Apoptosis, pubmed-meshheading:19280190-Carcinoma, Squamous Cell, pubmed-meshheading:19280190-Caspase 12, pubmed-meshheading:19280190-Caspases, Initiator, pubmed-meshheading:19280190-Cell Line, Tumor, pubmed-meshheading:19280190-Cinnamates, pubmed-meshheading:19280190-Cisplatin, pubmed-meshheading:19280190-Drug Synergism, pubmed-meshheading:19280190-Endoplasmic Reticulum, pubmed-meshheading:19280190-Enzyme Inhibitors, pubmed-meshheading:19280190-Eukaryotic Initiation Factor-2, pubmed-meshheading:19280190-Female, pubmed-meshheading:19280190-Heat-Shock Proteins, pubmed-meshheading:19280190-Histone Deacetylase Inhibitors, pubmed-meshheading:19280190-Humans, pubmed-meshheading:19280190-Hydroxamic Acids, pubmed-meshheading:19280190-In Situ Nick-End Labeling, pubmed-meshheading:19280190-Membrane Glycoproteins, pubmed-meshheading:19280190-Mouth Neoplasms, pubmed-meshheading:19280190-Phosphorylation, pubmed-meshheading:19280190-Protein Phosphatase 1, pubmed-meshheading:19280190-Proto-Oncogene Proteins c-akt, pubmed-meshheading:19280190-Thapsigargin, pubmed-meshheading:19280190-Thiourea, pubmed-meshheading:19280190-Tunicamycin, pubmed-meshheading:19280190-Valproic Acid
pubmed:year
2009
pubmed:articleTitle
Enhancement of cisplatin cytotoxicity by SAHA involves endoplasmic reticulum stress-mediated apoptosis in oral squamous cell carcinoma cells.
pubmed:affiliation
Department of Microbiology and Immunology, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't