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rdf:type |
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lifeskim:mentions |
umls-concept:C0012155,
umls-concept:C0015689,
umls-concept:C0026809,
umls-concept:C0026845,
umls-concept:C0204695,
umls-concept:C0289313,
umls-concept:C0332161,
umls-concept:C0442796,
umls-concept:C0920563,
umls-concept:C1157202,
umls-concept:C1280500
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pubmed:issue |
5
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pubmed:dateCreated |
2009-4-6
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pubmed:abstractText |
Fatty acids of marine origin, i.e. docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) act as hypolipidaemics, but they do not improve glycaemic control in obese and diabetic patients. Thiazolidinediones like rosiglitazone are specific activators of peroxisome proliferator-activated receptor gamma, which improve whole-body insulin sensitivity. We hypothesised that a combined treatment with a DHA and EPA concentrate (DHA/EPA) and rosiglitazone would correct, by complementary additive mechanisms, impairments of lipid and glucose homeostasis in obesity.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Corn Oil,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats,
http://linkedlifedata.com/resource/pubmed/chemical/Docosahexaenoic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Eicosapentaenoic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Omega-3,
http://linkedlifedata.com/resource/pubmed/chemical/Glycogen,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazolidinediones,
http://linkedlifedata.com/resource/pubmed/chemical/rosiglitazone
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1432-0428
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pubmed:author |
pubmed-author:BaranowskaEE,
pubmed-author:BryhnMM,
pubmed-author:BurcelinRR,
pubmed-author:CintiSS,
pubmed-author:FlachsPP,
pubmed-author:GorskiJJ,
pubmed-author:HensleyDD,
pubmed-author:JanovskaPP,
pubmed-author:JelenikTT,
pubmed-author:JilkovaZZ,
pubmed-author:KEMPC RCR,
pubmed-author:KazdovaLL,
pubmed-author:KopeckyJJ,
pubmed-author:KusVV,
pubmed-author:Mohamed-AliVV,
pubmed-author:OgstonNN,
pubmed-author:PolakJJ,
pubmed-author:RossmeislMM
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pubmed:issnType |
Electronic
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
941-51
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19277604-Animals,
pubmed-meshheading:19277604-Corn Oil,
pubmed-meshheading:19277604-Dietary Fats,
pubmed-meshheading:19277604-Docosahexaenoic Acids,
pubmed-meshheading:19277604-Eicosapentaenoic Acid,
pubmed-meshheading:19277604-Fatty Acids, Omega-3,
pubmed-meshheading:19277604-Glucose Intolerance,
pubmed-meshheading:19277604-Glycogen,
pubmed-meshheading:19277604-Hypoglycemic Agents,
pubmed-meshheading:19277604-Insulin,
pubmed-meshheading:19277604-Male,
pubmed-meshheading:19277604-Mice,
pubmed-meshheading:19277604-Mice, Inbred C57BL,
pubmed-meshheading:19277604-Muscle, Skeletal,
pubmed-meshheading:19277604-Thiazolidinediones
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pubmed:year |
2009
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pubmed:articleTitle |
n-3 fatty acids and rosiglitazone improve insulin sensitivity through additive stimulatory effects on muscle glycogen synthesis in mice fed a high-fat diet.
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pubmed:affiliation |
Department of Adipose Tissue Biology, Institute of Physiology of the Academy of Sciences of the Czech Republic, Prague, Czech Republic.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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