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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2009-3-11
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pubmed:abstractText |
Toll-like receptors (TLRs) play a critical role in sensing microbial components and inducing innate immune and inflammatory responses by recognizing invading microbial pathogens. Lipopolysaccharide-induced dimerization of TLR4 is required for the activation of downstream signaling pathways including nuclear factor-kappa B (NF-kappaB). Therefore, TLR4 dimerization may be an early regulatory event in activating ligand-induced signaling pathways and induction of subsequent immune responses. Here, we report biochemical evidence that 6-shogaol, the most bioactive component of ginger, inhibits lipopolysaccharide-induced dimerization of TLR4 resulting in the inhibition of NF-kappaB activation and the expression of cyclooxygenase-2. Furthermore, we demonstrate that 6-shogaol can directly inhibit TLR-mediated signaling pathways at the receptor level. These results suggest that 6-shogaol can modulate TLR-mediated inflammatory responses, which may influence the risk of chronic inflammatory diseases.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Catechols,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Luciferases,
http://linkedlifedata.com/resource/pubmed/chemical/MYD88 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mutagens,
http://linkedlifedata.com/resource/pubmed/chemical/Myd88 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Myeloid Differentiation Factor 88,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 4,
http://linkedlifedata.com/resource/pubmed/chemical/shogaol
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1016-8478
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
211-5
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pubmed:dateRevised |
2010-6-16
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pubmed:meshHeading |
pubmed-meshheading:19277504-Animals,
pubmed-meshheading:19277504-Catechols,
pubmed-meshheading:19277504-Cells, Cultured,
pubmed-meshheading:19277504-Cyclooxygenase 2,
pubmed-meshheading:19277504-Dimerization,
pubmed-meshheading:19277504-Immunoblotting,
pubmed-meshheading:19277504-Immunoprecipitation,
pubmed-meshheading:19277504-Kidney,
pubmed-meshheading:19277504-Lipopolysaccharides,
pubmed-meshheading:19277504-Luciferases,
pubmed-meshheading:19277504-Mice,
pubmed-meshheading:19277504-Monocytes,
pubmed-meshheading:19277504-Mutagens,
pubmed-meshheading:19277504-Myeloid Differentiation Factor 88,
pubmed-meshheading:19277504-NF-kappa B,
pubmed-meshheading:19277504-Plant Extracts,
pubmed-meshheading:19277504-Plasmids,
pubmed-meshheading:19277504-Signal Transduction,
pubmed-meshheading:19277504-Toll-Like Receptor 4,
pubmed-meshheading:19277504-Transfection
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pubmed:year |
2009
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pubmed:articleTitle |
Inhibition of homodimerization of toll-like receptor 4 by 6-shogaol.
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pubmed:affiliation |
Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University, Asan, 336-745, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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