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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-3-18
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pubmed:abstractText |
The E6 and E7 genes of human papillomavirus type 16 (HPV16) encode oncoproteins that bind and degrade p53 and retinoblastoma (pRb) tumor suppressors, respectively. We examined the effects of repressing E6 and E7 oncogene expression on the transformed phenotype of HPV16-positive oropharyngeal cancer cell lines.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Annexin A5,
http://linkedlifedata.com/resource/pubmed/chemical/E6 protein, Human papillomavirus...,
http://linkedlifedata.com/resource/pubmed/chemical/EID1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Papillomavirus E7 Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53,
http://linkedlifedata.com/resource/pubmed/chemical/oncogene protein E7, Human...
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1460-2105
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
18
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
412-23
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19276448-Annexin A5,
pubmed-meshheading:19276448-Apoptosis,
pubmed-meshheading:19276448-Carcinoma, Squamous Cell,
pubmed-meshheading:19276448-Cell Line, Tumor,
pubmed-meshheading:19276448-Cell Survival,
pubmed-meshheading:19276448-Flow Cytometry,
pubmed-meshheading:19276448-Gene Silencing,
pubmed-meshheading:19276448-Humans,
pubmed-meshheading:19276448-Immunoblotting,
pubmed-meshheading:19276448-In Situ Nick-End Labeling,
pubmed-meshheading:19276448-Nuclear Proteins,
pubmed-meshheading:19276448-Oncogene Proteins, Viral,
pubmed-meshheading:19276448-Oropharyngeal Neoplasms,
pubmed-meshheading:19276448-Papillomavirus E7 Proteins,
pubmed-meshheading:19276448-Papillomavirus Infections,
pubmed-meshheading:19276448-Phenotype,
pubmed-meshheading:19276448-RNA, Neoplasm,
pubmed-meshheading:19276448-Repressor Proteins,
pubmed-meshheading:19276448-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19276448-Tumor Suppressor Protein p53,
pubmed-meshheading:19276448-Tumor Virus Infections
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pubmed:year |
2009
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pubmed:articleTitle |
E6 and e7 gene silencing and transformed phenotype of human papillomavirus 16-positive oropharyngeal cancer cells.
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pubmed:affiliation |
Department of Medical Oncology, Yale University School of Medicine, New Haven, CT 06520, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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