Linked Life Data

19275758

Source:http://linkedlifedata.com/resource/pubmed/id/19275758

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-3-11
pubmed:abstractText
Myc family genes are often deregulated in embryonal tumors of childhood including medulloblastoma and neuroblastoma and are frequently associated with aggressive, poorly differentiated tumors. The Myc protein is a transcription factor that regulates a variety of cellular processes including cell growth and proliferation, cell cycle progression, differentiation, apoptosis, and cell motility. Potential strategies that either inhibit the proliferation-promoting effect of Myc and/or activate its pro-apoptotic function are presently being explored. In this review, we will give an overview of Myc activation in embryonal tumors and discuss current strategies aimed at targeting Myc for cancer treatment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1873-5576
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
176-88
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Targeting Myc in pediatric malignancies of the central and peripheral nervous system.
pubmed:affiliation
Department of Oncology, University Children's Hospital Zurich, Steinwiesstrasse 75, Zurich, Switzerland. Michael.Grotzer@kispi.uzh.ch
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't